ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Genetics in the pathogenesis of esophageal cancer: possible predictive and prognostic factors.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Computational identification of rare pathogenic genomic variants in esophageal cancer markers: Transcript-level analysis, sequence-based insights, and structural-functional impacts of non-synonymous SNPs.Biochemistry and biophysics reports · 2026Article
- Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/β-catenin signaling pathway.Thoracic cancer · 2019Article
- Surveillance or resection after chemoradiation in esophageal cancer.Annals of translational medicine · 2018Review
- Downregulation of RIKP by miR-200a promotes the invasive ability of esophageal cancer cells by upregulating the expression of LIN28 and MMP-14.International journal of clinical and experimental pathology · 2017Article
- UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.Oncology letters · 2015Article
- Clinicopathological significance of wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- The tumor suppressor LKB1 antagonizes WNT signaling pathway through modulating GSK3β activity in cell growth of esophageal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
- Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma.General thoracic and cardiovascular surgery · 2013Review
- Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma.World journal of gastroenterology · 2013Article
- Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma.PloS one · 2013Article
- Cytokines association with clinical and pathological changes in esophageal squamous cell carcinoma.Disease markers · 2013Review
- S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells.World journal of gastroenterology · 2012Article
- Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.Oncogene · 2012Article
- Slug down-regulation by RNA interference inhibits invasion growth in human esophageal squamous cell carcinoma.BMC gastroenterology · 2011Article
- Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Review
- Decreased expression of CIAPIN1 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.Digestive diseases and sciences · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEsophageal adenocarcinoma is the most rapidly increasing cancer in Western countries. Like esophageal squamous-cell carcinoma, these tumors are often detected at an advanced stage, requiring a multimodal concept. Despite improvements in detection, surgical resection, and (neo-) adjuvant therapy, the overall survival of esophageal cancer remains lower than other solid tumors. In fact, just 30-40% of the patients with advanced esophageal cancer benefit from a neoadjuvant therapy. Therefore, predictive/prognostic markers are needed to allow tailored multimodality therapy with increased efficacy. DISCUSSION: In recent years, there has been an exponential growth in our understanding of the cellular and molecular events associated with cell cycle regulation, programmed cell death, angiogenesis, and tumor growth. In this review, the classification of Hanahan and Weinberg is used concerning the six essential changes in carcinogenesis, i.e., the six hallmarks of cancer: (1) self-sufficiency in growth signals; (2) insensitivity to antigrowth signals; (3) avoidance of apoptosis; (4) limitless replicative potential; (5) sustained angiogenesis; and (6) tissue invasion and metastasis.
conclusionsAccording to these six steps, this review provides an update of the most recent data about predictive/prognostic molecular markers in patients with esophageal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.