ArticleLasers in medical science2010
Apoptosis- and necrosis-induced changes in light attenuation measured by optical coherence tomography.
Article in Lasers in medical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
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- Achieving High-Precision Attenuation Coefficient Measurement in Optical Coherence Tomography.Journal of biophotonics · 2025Article
- Dual-parameter tomographic imaging of attenuation and backscattering coefficients for quantitative evaluation of immune cell-mediated cytotoxicity in tumor spheroids.Theranostics · 2025Article
- Line-field dynamic optical coherence tomography platform for volumetric assessment of biological tissues.Biomedical optics express · 2024Article
- Theoretical and experimental determination of the confocal function of OCT systems for accurate calculation of sample optical properties.Biomedical optics express · 2024Article
- Dynamic optical coherence tomography for cell analysis [Invited].Biomedical optics express · 2023Review
- Multiparametric Quantitative Analysis of Photodamage to Skin Using Optical Coherence Tomography.Sensors (Basel, Switzerland) · 2023Article
- Deep learning-based optical coherence tomography image analysis of human brain cancer.Biomedical optics express · 2023Article
- The impacts of resveratrol on the retinal degeneration in a rat model of retinitis pigmentosa induced by alkylation: an in-vivo study.Animal cells and systems · 2023Article
- Precision of attenuation coefficient measurements by optical coherence tomography.Journal of biomedical optics · 2022Article
- Label-free, non-invasive, and repeatable cell viability bioassay using dynamic full-field optical coherence microscopy and supervised machine learning.Biomedical optics express · 2022Article
- Characterization and identification of cell death dynamics by quantitative phase imaging.Journal of biomedical optics · 2022Article
- Multiphysical numerical study of photothermal therapy of glioblastoma with photoacoustic temperature monitoring in a mouse head.Biomedical optics express · 2022Article
- Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography.Scientific reports · 2021Article
- Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy.Biomedical optics express · 2021Article
- Volumetric tumor delineation and assessment of its early response to radiotherapy with optical coherence tomography.Biomedical optics express · 2021Article
- Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems.Scientific reports · 2021Article
- Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation.Journal of biomedical optics · 2020Review
- Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.BMC ophthalmology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical coherence tomography (OCT) was used to determine optical properties of pelleted human fibroblasts in which necrosis or apoptosis had been induced. We analysed the OCT data, including both the scattering properties of the medium and the axial point spread function of the OCT system. The optical attenuation coefficient in necrotic cells decreased from 2.2 +/- 0.3 mm(1) to 1.3 +/- 0.6 mm(-1), whereas, in the apoptotic cells, an increase to 6.4 +/- 1.7 mm(-1) was observed. The results from cultured cells, as presented in this study, indicate the ability of OCT to detect and differentiate between viable, apoptotic, and necrotic cells, based on their attenuation coefficient. This functional supplement to high-resolution OCT imaging can be of great clinical benefit, enabling on-line monitoring of tissues, e.g. for feedback in cancer treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.