Evidence map›Paper›PMID 19756829›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2009

Circulating endocannabinoid concentrations during orthostatic stress.

Christoph Schroeder, Sandor Batkai, Stefan Engeli, Jens Tank, André Diedrich, Friedrich C Luft, Jens Jordan

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Trial
  2. Understanding the Role of Endocannabinoids in Posttraumatic Stress Disorder.International journal of molecular sciences · 2025
    Review
  3. Endocannabinoids as potential biomarkers: It's all about pre-analytics.Journal of mass spectrometry and advances in the clinical lab · 2021
    Article
  4. Article
  5. Article
  6. Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christoph SchroederFranz Volhard Clinical Research Center, Helios Klinikum-Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Sandor Batkai
Stefan Engeli
Jens Tank
André Diedrich
Friedrich C Luft
Jens Jordan

Funding

Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
NHLBI NIH HHS P01 HL056693
6 · The paper itself

Abstract

backgroundIn animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND

methodsWe tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope.

resultsWith head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged.

conclusionsIn contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.

Indexed as

EndocannabinoidsStress, PhysiologicalAdultArachidonic AcidsBlood PressureCannabinoid Receptor ModulatorsDizzinessFemaleGlyceridesHumansMaleOrthostatic IntolerancePolyunsaturated AlkamidesSympathetic Nervous SystemSyncopeTilt-Table TestanandamideArachidonic AcidsCannabinoid Receptor ModulatorsEndocannabinoidsGlyceridesglyceryl 2-arachidonatePolyunsaturated Alkamides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.