ArticleEuropean archives of psychiatry and clinical neuroscience2010
Brainstem raphe lesion in patients with major depressive disorder and in patients with suicidal ideation recorded on transcranial sonography.
Article in European archives of psychiatry and clinical neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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10 citing papers in PubMed, 29 citations in OpenAlex.
- Transcranial Sonographic Characteristics of Substantia Nigra in End-Stage Renal Disease Patients with Restless Legs Syndrome: A Diagnostic Marker Study.Diagnostics (Basel, Switzerland) · 2025Article
- State-of-the-Art Transcranial Sonography for Neuropsychiatric and Dementia Disorders: A Narrative Review.Cureus · 2025Review
- Article
- Hypoechogenicity of the midbrain raphe detected by transcranial sonography: an imaging biomarker for depression in migraine patients.Therapeutic advances in neurological disorders · 2021Article
- Shape Deformation in the Brainstem of Medication-Naïve Female Patients with Major Depressive Disorder.Psychiatry investigation · 2020Article
- The Significance of Brain Transcranial Sonography in Burning Mouth Syndrome: a Pilot Study.Acta stomatologica Croatica · 2017Article
- Alteration of brainstem raphe measured by transcranial sonography in depression patients with or without Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- The functional anatomy of psychomotor disturbances in major depressive disorder.Frontiers in psychiatry · 2015Review
- Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems.Biological psychiatry · 2014Article
- Vagus somatosensory evoked potentials are delayed in Alzheimer's disease, but not in major depression.European archives of psychiatry and clinical neuroscience · 2014Article
Corrections and comments
- Erratum issuedMislav, Budisic [corrected to Budisic, Mislav]; Dalibor, Karlovic [corrected to Karlovic, Dalibor]; Zlatko, Trkanjec [corrected to Trkanjec, Zlatko]; Airjana, Lovrencic-Huzjan [corrected to Lovrencic-Huzjan, Arijana]; Vlasta, Vukovic [corrected to Vukovic,
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent transcranial sonography (TCS) studies showed that disruption of echogenic midbrain line, corresponding to basal limbic system and raphe nuclei (RN) within, might represent functional marker for the development of depression. Major depressive disorder (MDD) is one of the most common psychiatric disorders associated with suicidal ideation. We initiated this study to assess the usefulness of TCS recording in a group of MDD patients and in MDD patients who also reported suicidal ideation, on the assumption that TCS might serve as a screening method for differentiating patients at risk of suicide. Altogether 71 subjects: 17 patients with MDD, 14 patients with MDD who also reported suicidal ideation and 40 healthy controls, were studied using TCS by two independent physicians. Reduced raphe echogenicity was found in 8 of 17 (47%) of the patients with MDD but only in 6 of 40 (15%) controls. In patients with suicidal ideations that finding was even more pronounced (12 of 14, 86%) with the highest frequency of completely not visible TCS RN finding (10 of 14, 72%). Data showed that altered echogenicity of the RN is frequent in patients with suicidal ideation. Normal RN echogenicity in MDD patients was associated with less severe depressive symptoms and rarely with the presence of suicidal ideations. As far as we know, these are the first ever obtained results which show that TCS might help differentiating MDD patients with suicidal risk or eventually predict good disease recovery based on the findings of RN hypo- or normoechogenicity.
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