ArticleFunctional & integrative genomics2010
Sex-dependent gene regulatory networks of the heart rhythm.
Article in Functional & integrative genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Gender differences in electrophysiological gene expression in failing and non-failing human hearts.PloS one · 2013Trial
- Neurotransmission Sex Dichotomy in the Rat Hypothalamic Paraventricular Nucleus in Healthy and Infantile Spasm Model.Current issues in molecular biology · 2025Article
- Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages.Toxicology · 2025Article
- Heart failure in diabetes.Metabolism: clinical and experimental · 2021Review
- Article
- Transcriptomic uniqueness and commonality of the ion channels and transporters in the four heart chambers.Scientific reports · 2021Article
- Powerful quantifiers for cancer transcriptomics.World journal of clinical oncology · 2020Review
- Article
- Sex differences in Alzheimer's disease and common neuropathologies of aging.Acta neuropathologica · 2018Article
- Sex Differences in Metabolic Cardiomyopathy.Cardiovascular research · 2017Article
- Estrogen regulation of protein expression and signaling pathways in the heart.Biology of sex differences · 2014Article
- The connexin43-dependent transcriptome during brain development: importance of genetic background.Brain research · 2012Article
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- Gap junctions and chagas disease.Advances in parasitology · 2011Review
- The position of mefloquine as a 21st century malaria chemoprophylaxis.Malaria journal · 2010Review
- Heart rhythm genomic fabric in hypoxia.Biochemical and biophysical research communications · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Expression level, control, and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of four male and four female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins, cadherins, plakophilins, and other components of the intercalated discs form a complex network that is chamber dependent and differs between the two sexes. In addition, most HRD genes in atria had higher expression in males than in females, while in ventricles, expression levels were mostly higher in females than in males. Moreover, significant chamber differences were observed between the sexes, with higher expression in atria than ventricles for males and higher expression in ventricles than atria for females. We have ranked the selected genes according to their prominence (new concept) within the HRD gene web defined as extent of expression coordination with the other web genes and stability of expression. Interestingly, the prominence hierarchy was substantially different between the two sexes. Taken together, these findings indicate that the organizational principles of the heart rhythm transcriptome are sex dependent, with the newly introduced prominence analysis allowing identification of genes that are pivotal for the sexual dichotomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.