ArticleParasitology research2009
Ex vivo and in vivo biological behavior of Leishmania (Viannia) shawi.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Leishmanicidal Activity and Ultrastructural Changes of Maslinic Acid Isolated fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis.Journal of immunology research · 2021Article
- Repurposing Butenafine as An Oral Nanomedicine for Visceral Leishmaniasis.Pharmaceutics · 2019Article
- Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Effect of phospholipase AThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Dynamic of the cellular immune response at the dermal site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis infection in Sapajus apella primate.BioMed research international · 2014Article
- Proteins of Leishmania (Viannia) shawi confer protection associated with Th1 immune response and memory generation.Parasites & vectors · 2012Article
- Leishmania (Viannia) shawi purified antigens confer protection against murine cutaneous leishmaniasis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae).Parasitology research · 2011Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the first description of Leishmania (Viannia) shawi, few studies were performed with this parasite. In the present work, the in vivo and ex vivo behavior of L. (Viannia) shawi infection was studied using murine model. Peritoneal macrophages from BALB/c and C57BL/6 mice were infected with promastigotes in the stationary phase of growth; after 24 h, the infection index and nitric oxide (NO) levels in the supernatant of the cultures were analyzed. BALB/c and C57BL/6 mice were infected into the hind footpad, and at each 2 weeks, mice were sacrificed, and the histological changes of the skin inoculation site, parasitism, and humoral immune responses were evaluated during 8 weeks. Ex vivo experiments showed that macrophages of BALB/c presented higher infection index and lesser NO levels than macrophages of C57BL/6. In vivo experiments showed that BALB/c presented higher lesion size than C57BL/6 mice; similarly, the histopathological changes and the parasitism in skin were more exacerbate in BALB/c mice. In draining lymph nodes, the main change was increase of germinative centers, and parasites were detected from 6 weeks pi onwards in both mice strain. IgG was detected in BALB/c mice from 4 weeks, while in C57BL/6, from 6 weeks pi onwards. Taken together, these results indicate that BALB/c showed a classical behavior of susceptibility when compared to C57BL/6 mice.
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