ArticleNeuroradiology2010
Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy--a pilot study at 1.5 T.
Article in Neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Current insights of applying MRI in Graves' ophthalmopathy.Frontiers in endocrinology · 2022Pooled it
- Quantitative Chemical Exchange Saturation Transfer MRI for Diagnosing Thyroid-Associated Ophthalmopathy Activity: A Prospective Feasibility Study.Korean journal of radiology · 2026Article
- SPECT/CT imaging in thyroid eye disease: an emerging role in assessing sub-clinical activity.Frontiers in ophthalmology · 2026Review
- Development and evaluation of AI model with deep learning for segmentation of extraocular muscles in thyroid eye disease.PloS one · 2026Article
- PDGFRαAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Orbital MRI and clinical activity score for predicting steroid treatment response in moderate-to-severe Graves' orbitopathy.Endocrine · 2025Article
- Diagnostic value of MRI and diffusion-weighted imaging in dysthyroid optic neuropathy: a cross-sectional study providing insights into predictive parameters and pathogenesis.Neuroradiology · 2025Article
- Lateral Rectus Muscle Resection for New-Onset Esotropia Following Medial Orbital Wall Decompression in Thyroid Eye Disease.Medicina (Kaunas, Lithuania) · 2025Observational
- Advancements in imaging research in thyroid-associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Assessment of disease activity in Graves' orbitopathy.Frontiers in ophthalmology · 2025Review
- Application progress of magnetic resonance imaging in thyroid associated ophthalmopathy.Frontiers in endocrinology · 2025Review
- Deep learning methods for diagnosis of graves' ophthalmopathy using magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- The evaluation of retrobulbar fat tissue in Graves' orbitopathy with shear-wave ultrasound elastography.International ophthalmology · 2024Article
- Computed tomography and magnetic resonance imaging approaches to Graves' ophthalmopathy: a narrative review.Frontiers in endocrinology · 2023Review
- Commentary: Dysthyroid optic neuropathy.Indian journal of ophthalmology · 2022Article
- The correlation of the neutrophil-lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease.Endocrine connections · 2022Article
- Imaging of the medial rectus muscle predicts the development of optic neuropathy in thyroid eye disease.Scientific reports · 2022Article
- Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy.European radiology · 2022Article
- Usefulness of two-point Dixon T2-weighted imaging in thyroid-associated ophthalmopathy: comparison with conventional fat saturation imaging in fat suppression quality and staging performance.The British journal of radiology · 2021Article
- Baseline Volumetric T2 Relaxation Time Histogram Analysis: Can It Be Used to Predict the Response to Intravenous Methylprednisolone Therapy in Patients With Thyroid-Associated Ophthalmopathy?Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response.
methodsIncluded in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) > or = 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle.
resultsSignal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS > or = 4 to discriminate active from inactive patients was statistically calculated.
conclusionT2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.