ArticlePsychopharmacology2009
A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat.
Article in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Effects of benztropine analogs on delay discounting in rats.Psychopharmacology · 2020Article
- Tamoxifen Directly Interacts with the Dopamine Transporter.The Journal of pharmacology and experimental therapeutics · 2018Article
- Dopamine Transporter Dynamics ofThe Journal of pharmacology and experimental therapeutics · 2018Article
- Behavioral economic analysis of the effects of N-substituted benztropine analogs on cocaine self-administration in rats.Psychopharmacology · 2018Article
- σ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration.The Journal of pharmacology and experimental therapeutics · 2017Article
- Further delineation between typical and atypical dopamine uptake inhibitors: effects on food-maintained behavior and food consumption.Behavioural pharmacology · 2017Article
- Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications.Frontiers in neuroscience · 2016Review
- Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamine.Biological psychiatry · 2014Article
- Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.The Journal of pharmacology and experimental therapeutics · 2014Article
- The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration.Psychopharmacology · 2013Article
- Article
- N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects.The Journal of pharmacology and experimental therapeutics · 2011Article
- Monoamine transporters: vulnerable and vital doorkeepers.Progress in molecular biology and translational science · 2011Review
- Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.The Journal of pharmacology and experimental therapeutics · 2010Article
- Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.Advances in pharmacology (San Diego, Calif.) · 2009Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleN-substituted benztropine analogs are potent dopamine uptake inhibitors that display pharmacokinetic/dynamic properties consistent with the profile of a substitute medication for cocaine addiction.
objectivesThe purpose of the present experiments was to characterize in rats the addictive-like properties of one such analog, 3 alpha-[bis(4'-fluorophenyl)methoxy]-tropane (AHN-1055), incorporating probes of its stimulant and incentive/motivational effects and of its ability to influence cocaine self-administration.
methodsWe used open field activity and drug self-administration assays. To examine the effects of AHN-1055 on locomotor behavior, the analog was administered alone (0, 1, 3, and 10 mg/kg intraperitoneally) and in combination with cocaine (15 mg/kg i.p.). The influence of AHN-1055 on cocaine's intake was studied by administering the analog (0, 3, and 10 mg/kg i.p.) before the start of the self-administration sessions. To compare the addictive-like properties of AHN-1055 and cocaine, progressive ratio performance and abstinence-induced context-conditioned relapse were evaluated.
resultsAHN-1055 evoked robust and sustained locomotor activity when administered alone and increased cocaine-induced locomotor stimulation. Notably, the analog showed by comparison to cocaine weak reinforcing efficacy in a modified progressive ratio schedule of drug reinforcement, and contrary to cocaine, it showed no ability to promote context-conditioned relapse to drug seeking following stable self-administration and abstinence. Further, AHN-1055 treatment blocked cocaine intake dose-dependently in rats with a steady history of cocaine self-administration without reducing responding for sucrose, a natural reward.
conclusionsThese findings demonstrate essential psychopharmacological differences between AHN-1055 and cocaine and highlight important properties of the analog as a possible pharmacotherapy in cocaine addiction.
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