ArticleDiabetologia2009
Beta cell (dys)function in non-diabetic offspring of diabetic patients.
Article in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial.Diabetologia · 2015Trial
- Relevance of the KATP channel function for the basal insulin hypersecretion of islets from female NZO mice.Journal of the Endocrine Society · 2026Article
- Effects of family history and sex on diabetes-related outcome in type 2 diabetes - Analysis from the tyrolean diabetes registry.PloS one · 2025Article
- HOMA-IR and the Matsuda Index as predictors of progression to type 1 diabetes in autoantibody-positive relatives.Diabetologia · 2024Article
- Dysregulation of β-Cell Proliferation in Diabetes: Possibilities of Combination Therapy in the Development of a Comprehensive Treatment.Biomedicines · 2022Review
- Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology.International journal of molecular sciences · 2022Review
- Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes.Healthcare (Basel, Switzerland) · 2021Article
- What Is the Metabolic Amplification of Insulin Secretion and Is It (Still) Relevant?Metabolites · 2021Review
- Article
- First-degree family history of diabetes and its relationship with serum osteocalcin levels independent of liver fat content in a non-diabetic Chinese cohort.BMC public health · 2019Article
- Inverse association between physical activity and blood glucose is independent of sex, menopause status and first-degree family history of diabetes.Journal of diabetes investigation · 2019Article
- Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.BMC endocrine disorders · 2017Article
- Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution.International journal of obesity (2005) · 2016Article
- Elevation in fibroblast growth factor 23 and its value for identifying subclinical atherosclerosis in first-degree relatives of patients with diabetes.Scientific reports · 2016Article
- Disproportionately Elevated Proinsulin Levels as an Early Indicator ofInternational journal of endocrinology · 2016Article
- Metabolic predictors of impaired glucose tolerance and type 2 diabetes in a predisposed population--A prospective cohort study.BMC endocrine disorders · 2015Article
- Clinical study of exercise on improvement of β-cell function and insulin resistance in non-diabetic young offsprings of diabetic patients.Journal of endocrinological investigation · 2014Article
- Whole-body insulin sensitivity rather than body-mass-index determines fasting and post-glucose-load growth hormone concentrations.PloS one · 2014Article
- Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe first-degree offspring of patients with type 2 diabetes are prone to develop type 2 diabetes, and have both insulin resistance and beta cell impairment. However, it is still unclear whether both pathophysiological features are inseparably combined and which is the outstanding determinant in the offspring.
methodsGlucose metabolism, insulin sensitivity (calculated as M value divided by insulin [M/I]) and beta cell function were studied in the offspring of individuals with type 2 diabetes (n = 187; 57% females; age 43.8 +/- 8.1 years; BMI 26.8 +/- 4.5 kg/m(2)) and in individuals without a family history of type 2 diabetes (controls, n = 519, 55% females; age 43.4 +/- 8.2 years; BMI 26.4 +/- 3.7 kg/m(2), no significant differences between the groups for any characteristic) by performance of 75 g OGTT and 2 h hyperinsulinaemic (40 mU min(-1) m(-2))-isoglycaemic clamp tests. Beta cell function was evaluated by calculating insulinogenic index (IGI) from C-peptide AUC:glucose AUC ratios from the first hour of OGTT (IGI[60 min]) and from the total OGTT (IGI[120 min]).
resultsDuring the OGTT, the offspring of individuals with type 2 diabetes showed 4-14% higher plasma glucose from 30 to 120 min (p < 0.05) and 20-29% higher serum insulin from 90 to 120 min, but decreased IGI(60 min) and IGI(120 min) (p < 0.05). M/I was 11% lower in the offspring of affected individuals than in controls (p < 0.01). To study the offspring of patients with type 2 diabetes with insulin sensitivity similar to that of the control group, the offspring of affected patients were divided into M/I quartiles. Those in the third M/I quartile showed M/I values and major anthropometric characteristics similar to those of the controls, but insulin AUC and C-peptide AUC values were lower in the first hour and the total OGTT (p < 0.05). The third M/I quartile had lower IGI values at 60 min and 120 min: 11% and 14% lower, respectively (p < 0.02). CONCLUSIONS/
interpretationThe first-degree offspring of type 2 diabetic patients show insulin resistance and beta cell dysfunction in response to oral glucose challenge. Beta cell impairment exists in insulin-sensitive offspring of patients with type 2 diabetes, suggesting beta cell dysfunction to be a major defect determining diabetes development in diabetic offspring.
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