ArticleEuropean journal of dentistry2009
Effect of ED-71, a New Active Vitamin D Analog, on Bone Formation in an Orthopedically Expanded Suture in Rats. A Histomorphometric Study.
Article in European journal of dentistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of platelet rich plasma injection on bone formation in the expanded mid-palatal suture in rabbits: a randomized controlled animal study.BMC oral health · 2024Article
- The role of Vitamin D as an adjunct for bone regeneration: A systematic review of literature.The Saudi dental journal · 2023Review
- Effect of Injectable platelet-rich fibrin (i-PRF) on new bone formation in surgical expansion with mini-screw assisted rapid palatal expander: A dog model study.Journal of orthodontic science · 2023Article
- Effect of Vitamin D on Bone Regeneration: A Review.Medicina (Kaunas, Lithuania) · 2022Review
- Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion.Dental press journal of orthodontics · 2022Article
- Rapid Palatal Expansion Should Not Be Trivialized: Two Case Reports of Unexpected Complications.European journal of dentistry · 2021Article
- Effect of mesenchymal stem cells injection and low-level laser therapy on bone formation after rapid maxillary expansion: an animal study.American journal of stem cells · 2020Article
- Stimulatory effects of simvastatin on bone regeneration of the expanded suture in rats.American journal of translational research · 2020Article
- Effects of different settings for 940 nm diode laser on expanded suture in rats.The Angle orthodontist · 2019Article
- Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen-nanodiamond hydrogel.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The effect of different concentrations of topical ozone administration on bone formation in orthopedically expanded suture in rats.European journal of orthodontics · 2016Article
- Re: bone marrow mesenchymal stem cells enhance bone formation in orthodontically expanded maxillae in rats. Abdullah Ekizer, Mehmet Emir Yalvac, Tancan Uysal, Mehmet Fatih Sonmez, Fikrettin Sahin. The Angle Orthodontist. Online Early.The Angle orthodontist · 2015Article
- Effects of eldecalcitol on cortical bone response to mechanical loading in rats.BMC musculoskeletal disorders · 2015Article
- Bone marrow mesenchymal stem cells enhance bone formation in orthodontically expanded maxillae in rats.The Angle orthodontist · 2015Article
- Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture.Drug design, development and therapy · 2015Article
- The effect of dosage on the efficiency of LLLT in new bone formation at the expanded suture in rats.Lasers in medical science · 2015Article
- Effect of dietary ascorbic Acid on osteogenesis of expanding midpalatal suture in rats.Journal of dentistry (Tehran, Iran) · 2015Article
- Effects of strontium ranelate on bone formation in the mid-palatal suture after rapid maxillary expansion.Drug design, development and therapy · 2015Article
- Light-emitting diode photobiomodulation: effect on bone formation in orthopedically expanded suture in rats--early bone changes.Lasers in medical science · 2013Article
- Systemic propolis stimulates new bone formation at the expanded suture: a histomorphometric study.The Angle orthodontist · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this experimental study was to evaluate the effects of ED-71, a new active vitamin D analog, on bone regeneration in response to expansion of the mid-palatal suture, in rats, histomorphometrically.
methodsSixteen male 50-60 days old Wistar rats were separated into two equal groups (control and experimental). Both groups were subjected to expansion, and 30 grams of force was applied to the maxillary incisors with a helical-spring. Experimental group was treated with single-dose ED-71 (0.8 mug/kg body weight) in the mid-palatal suture locally and eight control animals received vehicle solution. Bone regeneration in the mid-palatal suture was evaluated by bone histomorphometric method and mineralized area (Md.Ar), fibrosis area (Fb.Ar), mineralized area/fibrosis area (Md.Ar/Fb.Ar), bone area (B.Ar) and osteoblast number (N.Ob) parameters were evaluated. Mann Whitney-U test was used for statistical evaluation at P<.05 level.
resultsStatistical analysis showed significant differences between groups for all investigated histomorphometric parameters. Md.Ar (P<.001), Md.Ar/Fb.Ar (P<.001), B.Ar (P<.01) and N.Ob (P<.001) parameters were significantly increased and Fb.Ar (P<.001) measurement was significantly decreased in experimental group. ED-71 group with a mean of 24.55+/-6.47 showed statistically higher N.Ob than the control group (mean N.Ob: 12.82+/-5.81).
conclusionsED-71 has positive effects on early phase of bone regeneration in the mid-palatal suture in response to expansion and may be beneficial in routine maxillary expansion procedures.
Indexed as
Identifiers
19756189PMC2741186W5736836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.