ArticlePloS one2009
Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- DEER Analysis of GPCR Conformational Heterogeneity.Biomolecules · 2021Review
- Modulating TSH Receptor Signaling for Therapeutic Benefit.European thyroid journal · 2020Article
- Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1.Cellular and molecular life sciences : CMLS · 2017Article
- GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.Nucleic acids research · 2017Article
- Methods for the Development of In Silico GPCR Models.Methods in enzymology · 2017Article
- Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.Frontiers in endocrinology · 2017Review
- Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications.PLoS computational biology · 2016Article
- The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases.The Journal of biological chemistry · 2016Article
- Free fatty acid receptors: structural models and elucidation of ligand binding interactions.BMC structural biology · 2015Article
- Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.The Journal of biological chemistry · 2015Article
- Novel insights on thyroid-stimulating hormone receptor signal transduction.Endocrine reviews · 2013Review
- Molecular dynamics simulations on the Tre1 G protein-coupled receptor: exploring the role of the arginine of the NRY motif in Tre1 structure.BMC structural biology · 2013Article
- Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.The Journal of biological chemistry · 2013Article
- G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.PloS one · 2013Article
- Towards improved quality of GPCR models by usage of multiple templates and profile-profile comparison.PloS one · 2013Article
- GOMoDo: A GPCRs online modeling and docking webserver.PloS one · 2013Article
- The antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.The Journal of biological chemistry · 2012Article
- Modeling of mammalian olfactory receptors and docking of odorants.Biophysical reviews · 2012Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUp until recently the only available experimental (high resolution) structure of a G-protein-coupled receptor (GPCR) was that of bovine rhodopsin. In the past few years the determination of GPCR structures has accelerated with three new receptors, as well as squid rhodopsin, being successfully crystallized. All share a common molecular architecture of seven transmembrane helices and can therefore serve as templates for building molecular models of homologous GPCRs. However, despite the common general architecture of these structures key differences do exist between them. The choice of which experimental GPCR structure(s) to use for building a comparative model of a particular GPCR is unclear and without detailed structural and sequence analyses, could be arbitrary. The aim of this study is therefore to perform a systematic and detailed analysis of sequence-structure relationships of known GPCR structures. METHODOLOGY: We analyzed in detail conserved and unique sequence motifs and structural features in experimentally-determined GPCR structures. Deeper insight into specific and important structural features of GPCRs as well as valuable information for template selection has been gained. Using key features a workflow has been formulated for identifying the most appropriate template(s) for building homology models of GPCRs of unknown structure. This workflow was applied to a set of 14 human family A GPCRs suggesting for each the most appropriate template(s) for building a comparative molecular model.
conclusionsThe available crystal structures represent only a subset of all possible structural variation in family A GPCRs. Some GPCRs have structural features that are distributed over different crystal structures or which are not present in the templates suggesting that homology models should be built using multiple templates. This study provides a systematic analysis of GPCR crystal structures and a consistent method for identifying suitable templates for GPCR homology modelling that will help to produce more reliable three-dimensional models.
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