ArticlePloS one2009
Resolving the role of actoymyosin contractility in cell microrheology.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells.Acta biomaterialia · 2023Article
- Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension.PNAS nexus · 2023Article
- Particle tracking microrheology of cancer cells in living subjects.Materials today (Kidlington, England) · 2020Article
- Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells.Scientific reports · 2018Article
- A comparison of methods to assess cell mechanical properties.Nature methods · 2018Article
- Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.Scientific reports · 2017Article
- Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots.Nature communications · 2017Article
- Mapping intracellular mechanics on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.Journal of cellular and molecular medicine · 2015Article
- A high throughput array microscope for the mechanical characterization of biomaterials.The Review of scientific instruments · 2015Article
- Spatially coordinated changes in intracellular rheology and extracellular force exertion during mesenchymal stem cell differentiation.Physical biology · 2014Article
- Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy.Cell · 2014Article
- Rear actomyosin contractility-driven directional cell migration in three-dimensional matrices: a mechano-chemical coupling mechanism.Journal of the Royal Society, Interface · 2014Review
- The effect of enterohemorrhagic E. coli infection on the cell mechanics of host cells.PloS one · 2014Article
- Article
- Focal adhesion size uniquely predicts cell migration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Keratinocyte cytoskeletal roles in cell sheet engineering.BMC biotechnology · 2013Article
- Optical trapping microrheology in cultured human cells.The European physical journal. E, Soft matter · 2012Article
- High-throughput ballistic injection nanorheology to measure cell mechanics.Nature protocols · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Einstein's original description of Brownian motion established a direct relationship between thermally-excited random forces and the transport properties of a submicron particle in a viscous liquid. Recent work based on reconstituted actin filament networks suggests that nonthermal forces driven by the motor protein myosin II can induce large non-equilibrium fluctuations that dominate the motion of particles in cytoskeletal networks. Here, using high-resolution particle tracking, we find that thermal forces, not myosin-induced fluctuating forces, drive the motion of submicron particles embedded in the cytoskeleton of living cells. These results resolve the roles of myosin II and contractile actomyosin structures in the motion of nanoparticles lodged in the cytoplasm, reveal the biphasic mechanical architecture of adherent cells-stiff contractile stress fibers interdigitating in a network at the cell cortex and a soft actin meshwork in the body of the cell, validate the method of particle tracking-microrheology, and reconcile seemingly disparate atomic force microscopy (AFM) and particle-tracking microrheology measurements of living cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.