Evidence map›Paper›PMID 19756028›Full record

Trial reportEuropean journal of clinical nutrition2010

Nut consumption and risk of type II diabetes in the Physicians' Health Study.

J Kochar, J M Gaziano, L Djoussé

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Nut consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2015
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
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  11. Article
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  17. Nuts and berries for heart health.Current atherosclerosis reports · 2010
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J KocharDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
J M Gaziano
L Djoussé

Funding

Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
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NCI NIH HHS CA-097193NCI NIH HHS CA-34944NCI NIH HHS CA-40360NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NHLBI NIH HHS HL-26490NHLBI NIH HHS HL-34595NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595
6 · The paper itself

Abstract

BACKGROUND/

objectivesWhile type II diabetes (DM) is a major cause of morbidity in the United States, limited data are available on the association between nut intake and incident DM. We sought to examine the association between nut consumption and the risk of DM. SUBJECTS/

methodsProspective cohort of 20 224 male participants of the Physicians' Health Study I. Nut consumption was estimated using a 19-item brief food frequency questionnaire, and incident DM was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of DM.

resultsThe average age of the study participants was 54.4+/-9.4 years (range: 40.7-87.1). During a mean follow-up of 19.2 years, 1828 cases of DM occurred. The crude incidence rates of DM were 4.82, 4.85, 4.92, 4.16, 4.29 and 3.32 cases per 1000 person-years for individuals reporting nut consumption of rarely/never, <1, 1, 2-4, 5-6 and 7+ servings per week, respectively. While nut consumption was associated with a lower risk of DM in a model adjusted for age (P for tend 0.017), such relation was attenuated on additional control for other confounders (multivariable adjusted hazard ratios (95% confidence interval) for DM were 1.0 (reference), 1.06 (0.93-1.20), 1.10 (0.95-1.26), 0.97 (0.82-1.14), 0.99 (0.76-1.30) and 0.87 (0.61-1.24) from the lowest to the highest category of nut consumption, respectively (P for trend 0.99). No statistically significant association between nut consumption and DM was found in either lean or overweight/obese participants.

conclusionsOur data do not show an association between nut consumption and incident DM in US male physicians.

Indexed as

DietNutsDiabetes Mellitus, Type 2Diet SurveysHumansIncidenceMaleMiddle AgedModels, BiologicalProportional Hazards ModelsRisk FactorsSurveys and Questionnaires

Identifiers

PMID19756028
PMCPMC2802656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.