ReviewNature reviews. Microbiology2009
Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.
Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 403 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
403 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Leptospira in Brazilian Bats (Mammalia: Chiroptera): A Systematic Review.Veterinary medicine and science · 2025Pooled it
- A systematic review and meta-analysis of the epidemiology of Leptospirosis in HIV uninfected and in people living with HIV from the Southern African Development Community.PLoS neglected tropical diseases · 2022Pooled it
- Pooled it
- A systematic review ofOne health (Amsterdam, Netherlands) · 2026Article
- Cross-sectional investigation of pathogenic Leptospira at the wildlife-livestock interface in a Cerrado-Atlantic Forest ecotone, Brazil.Tropical animal health and production · 2026Article
- Molecular epidemiology of pathogenic Leptospira spp. in Thailand during 2024-2025, with detection of Leptospira weilii in human clinical specimens.PLoS neglected tropical diseases · 2026Article
- Environmental Distribution of Pathogenic Leptospira spp. in Subtropical Rivers of Japan and Implications for Human Infection.Tropical medicine & international health : TM & IH · 2026Article
- First report of seropositivity to pathogenic Leptospira in backyard hens: potential poultry health issue and zoonotic risk.Poultry science · 2026Article
- Core-sheath coupling controls flagellar curvature and motility in Leptospira.Nature communications · 2026Article
- AlphaFold reveals how pathogenicmBio · 2026Article
- Clinical and molecular characterization of an outbreak of leptospirosis in dogs from Los Angeles County, California, USA, 2021.Journal of clinical microbiology · 2026Article
- Multi-omics analysis of human patient samples identifies key immune factors inMicrobiology spectrum · 2026Article
- Leptospirosis presenting with fever, jaundice, and generalized lymphadenopathy: a case report with diagnostic challenges.Annals of medicine and surgery (2012) · 2026Article
- Clinical and epidemiological characteristics of leptospirosis in patients under and over 5 years of age in primary health centers in the Peruvian Amazon, 2022-2024.PLoS neglected tropical diseases · 2026Article
- Molecular detection and genetic characterisation of a large flood-borne outbreak of human leptospirosis in Jakarta, Indonesia: A retrospective analysis of surveillance data.PLoS neglected tropical diseases · 2026Article
- Artificial Irrigation Impacts the Seasonal Occurrence of Pathogenic Leptospira in Its Wild Reservoirs in a Mediterranean Environment.Zoonoses and public health · 2026Article
- Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira.Nature communications · 2026Article
- CRISPR-based mutagenesis of lipopolysaccharide biosynthesis genes in Leptospira interrogans reveals gene essentiality and confirms the role of an O-antigen polymerase.Scientific reports · 2026Article
- Genomic analysis of human-infecting Leptospira borgpetersenii isolates in Sri Lanka: Expanded PF07598 gene family repertoire and less genome reduction than bovine isolates.PLoS neglected tropical diseases · 2026Article
- DMEM and EMEM as alternate growth media for pathogenic Leptospira.PLoS neglected tropical diseases · 2026Article
343 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.