Chemotherapy for early-stage breast cancer: a brief history.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. The chemobrain in breast cancer patients: a systematic review and meta-analysis.Scientific reports · 2025
   Pooled it
2. Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta-analysis.International journal of cancer · 2023
   Pooled it
3. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis.Journal of the National Cancer Institute · 2015
   Pooled it
4. Clinician- and facility-level factors associated with chemotherapy dose reductions in stages I-IIIA breast cancer.Journal of the National Cancer Institute · 2026
   Article
5. Evolution of Breast Cancer Treatment 2010-2023.Annals of surgical oncology · 2026
   Article
6. The Role of Molecular Profiling in De-Escalation of Toxic Therapy in Breast Cancer.International journal of molecular sciences · 2025
   Review
7. Implications of Cyclophosphamide, Methotrexate, and 5-Flurouracil Chemotherapy on Hippocampal-Dependent Cognition and Gut-Microbiome.Frontiers in microbiomes · 2025
   Article
8. Breast cancer immunotherapy: a comprehensive review.Clinical and experimental medicine · 2023
   Review
9. Association of Circulating Levels of Inflammatory Cytokines and Chemotherapy-Associated Subjective Cognitive Impairment in a South African Cohort of Breast Cancer Patients.NeuroSci · 2023
   Article
10. Implications of Breast Cancer Chemotherapy-Induced Inflammation on the Gut, Liver, and Central Nervous System.Biomedicines · 2021
    Review
11. Chemotherapy-related subjective cognitive impairment in breast cancer patients in semi-rural South Africa.Health SA = SA Gesondheid · 2021
    Article
12. Prevalence of symptomatic dry eye in breast cancer patients undergoing systemic adjuvant treatment: A cross-sectional study.Breast (Edinburgh, Scotland) · 2020
    Article
13. Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup - the "ATRESS" phenomenon.Breast (Edinburgh, Scotland) · 2020
    Article
14. Comparison of Breast Conserving Surgery Followed by Radiation Therapy with Mastectomy Alone for Pathologic N1 Breast Cancer Patients in the Era of Anthracycline Plus Taxane-Based Chemotherapy: A Multicenter Retrospective Study (KROG 1418).Cancer research and treatment · 2019
    Article
15. Exploring circulating micro-RNA in the neoadjuvant treatment of breast cancer.International journal of cancer · 2016
    Review
16. Antitumor effect of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles on mice bearing breast cancer: a systemic toxicity assay.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
17. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.Molecular cancer therapeutics · 2014
    Article
18. Dextran-functionalized magnetic fluid mediating magnetohyperthermia for treatment of Ehrlich-solid-tumor-bearing mice: toxicological and histopathological evaluations.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
19. The Direct Medical Costs of Breast Cancer in Iran: Analyzing the Patient's Level Data from a Cancer Specific Hospital in Isfahan.International journal of preventive medicine · 2013
    Article
20. Breast cancer medications and vision: effects of treatments for early-stage disease.Current eye research · 2011
    Review

Corrections and comments

• Commented on by
  Breast cancer: Improved care through effective management of febrile neutropenia. Foreword.2009

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as