ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2010
Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity.The Biochemical journal · 2020Review
- Targeting Casein Kinase 1 (CK1) in Hematological Cancers.International journal of molecular sciences · 2020Review
- DDX3 binding with CK1ε was closely related to motor neuron degeneration of ALS by affecting neurite outgrowth.American journal of translational research · 2017Article
- Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.Genes, brain, and behavior · 2016Article
- Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.Molecular pain · 2014Article
- The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.Frontiers in oncology · 2014Review
- Article
- Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.Journal of molecular neuroscience : MN · 2012Article
- Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Article
- Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.Journal of neurochemistry · 2011Article
- Identification of early molecular markers for breast cancer.Molecular cancer · 2011Article
- Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε.PloS one · 2011Article
- Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action.Advanced drug delivery reviews · 2010Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Casein kinase 1 epsilon (CK1epsilon) is involved in various cellular processes, including cell growth, differentiation, and apoptosis, vesicle transport, and control of the circadian rhythm. Deregulation of CK1epsilon has been linked to neurodegenerative diseases and cancer. To better understand the cell type-specific functions of CK1epsilon, we determined its localization by immunhistochemistry in tissues of healthy, young adult BALB/c mice and in mammary tumors of SV40 T-antigen-transgenic mice. CK1epsilon expression was found to be highly regulated in normal tissues of endodermal, mesodermal, and ectodermal origin and in neoplastic tissue of mammary cancer. The data presented here give an overview of CK1epsilon reactivity in different organs under normal conditions and outline changes in its expression in mammary carcinomas. Our data suggest a cell/organ type-specific function of CK1epsilon and indicate that tumorigenic conversion of mammary glands in SV40 T-antigen-transgenic mice leads to downregulation of CK1epsilon. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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