ArticleAmerican journal of physiology. Endocrinology and metabolism2009
Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue.
Article in American journal of physiology. Endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Sustained Accumulation of Molecular Clock Suppressors Period 1 and Period 2 Promotes C2C12 Myotube Atrophy Through an Autocrine-Mediated Mechanism With Relevance to Androgen Deprivation-Induced Limb Muscle Mass Loss.Function (Oxford, England) · 2025Article
- Description of metabolic differences between castrated males and intact gilts obtained from high-throughput metabolomics of porcine plasma.Journal of animal science · 2025Article
- Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The effect of long-term hypogonadism on body composition and morphometry of aged male Wistar rats.Physiological research · 2021Article
- Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation.Molecular and cellular endocrinology · 2021Article
- Article
- Effects of mineral methionine hydroxy analog chelate in sow diets on epigenetic modification and growth of progeny.Journal of animal science · 2020Article
- Disruptions to the limb muscle core molecular clock coincide with changes in mitochondrial quality control following androgen depletion.American journal of physiology. Endocrinology and metabolism · 2019Article
- 17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males.Aging cell · 2019Article
- Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view.British journal of pharmacology · 2017Review
- Androgen-mediated regulation of skeletal muscle protein balance.Molecular and cellular endocrinology · 2017Review
- Inability to replete white adipose tissue during recovery phase of sepsis is associated with increased autophagy, apoptosis, and proteasome activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Castration alters protein balance after high-frequency muscle contraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Testosterone: Relationships with Metabolic Disorders in Men-An Observational Study from SPECT-China.International journal of endocrinology · 2017Article
- Alcohol Differentially Alters Extracellular Matrix and Adhesion Molecule Expression in Skeletal Muscle and Heart.Alcoholism, clinical and experimental research · 2015Article
- Article
- Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.Molecular and cellular endocrinology · 2013Article
- Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.Endocrinology and metabolism clinics of North America · 2012Review
- Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.Molecular and cellular biochemistry · 2011Article
- Limb, respiratory, and masticatory muscle compartmentalization: developmental and hormonal considerations.Progress in brain research · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Reduced testosterone as a result of catabolic illness or aging is associated with loss of muscle and increased adiposity. We hypothesized that these changes in body composition occur because of altered rates of protein synthesis under basal and nutrient-stimulated conditions that are tissue specific. The present study investigated such mechanisms in castrated male rats (75% reduction in testosterone) with demonstrated glucose intolerance. Over 9 wk, castration impaired body weight gain, which resulted from a reduced lean body mass and preferential sparing of adipose tissue. Castration decreased gastrocnemius weight, but this atrophy was not associated with reduced basal muscle protein synthesis or differences in plasma IGF-I, insulin, or individual amino acids. However, oral leucine failed to normally stimulate muscle protein synthesis in castrated rats. In addition, castration-induced atrophy was associated with increased 3-methylhistidine excretion and in vitro-determined ubiquitin proteasome activity in skeletal muscle, changes that were associated with decreased atrogin-1 or MuRF1 mRNA expression. Castration decreased heart and kidney weight without reducing protein synthesis and did not alter either cardiac output or glomerular filtration. In contradistinction, the weight of the retroperitoneal fat depot was increased in castrated rats. This increase was associated with an elevated rate of basal protein synthesis, which was unresponsive to leucine stimulation. Castration also decreased whole body fat oxidation. Castration increased TNFα, IL-1α, IL-6, and NOS2 mRNA in fat but not muscle. In summary, the castration-induced muscle wasting results from an increased muscle protein breakdown and the inability of leucine to stimulate protein synthesis, whereas the expansion of the retroperitoneal fat depot appears mediated in part by an increased basal rate of protein synthesis-associated increased inflammatory cytokine expression.
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