ReviewJournal of biological rhythms2009
Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.
Review in Journal of biological rhythms, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices.Protein science : a publication of the Protein Society · 2022Article
- Uncovering functional signature in neural systems via random matrix theory.PLoS computational biology · 2019Article
- Circadian disruption and breast cancer: an epigenetic link?Oncotarget · 2015Review
- Photoperiodic time measurement and seasonal immunological plasticity.Frontiers in neuroendocrinology · 2015Review
- Circadian rhythms and mood: opportunities for multi-level analyses in genomics and neuroscience: circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Sex differences in circadian timing systems: implications for disease.Frontiers in neuroendocrinology · 2014Review
- The role of the circadian system in fractal neurophysiological control.Biological reviews of the Cambridge Philosophical Society · 2013Review
- A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus.Neuron · 2013Article
- The clock shop: coupled circadian oscillators.Experimental neurology · 2013Review
- Persistent impairments in hippocampal, dorsal striatal, and prefrontal cortical function following repeated photoperiod shifts in rats.Experimental brain research · 2013Article
- Twelve-hour days in the brain and behavior of split hamsters.The European journal of neuroscience · 2012Article
- Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent.Journal of neuroendocrinology · 2012Article
- Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Dose-dependent effects of androgens on the circadian timing system and its response to light.Endocrinology · 2012Article
- Chronobiological approaches to Alzheimer's disease.Current Alzheimer research · 2012Review
- Androgens modulate structure and function of the suprachiasmatic nucleus brain clock.Endocrinology · 2011Article
- Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleus.PloS one · 2011Article
- Neuropeptide-mediated calcium signaling in the suprachiasmatic nucleus network.The European journal of neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to variations in operating environment (robustness), and following damage to components of the system (resilience), provide insight into the mechanisms whereby the SCN orchestrates circadian timing. Tissue level rhythmicity reveals circuits associated with an orderly spatiotemporal daily pattern of activity that is not predictable from their cellular elements. Specifically, in stable state, some SCN regions express low amplitude or undetectable rhythms in clock gene expression while others produce high amplitude oscillations. Within the SCN, clock gene expression follows a spatially ordered, repeated pattern of activation and inactivation. This pattern of activation is plastic and subserves responses to changes in external and internal conditions. Just as daily rhythms at the cellular level depend on sequential expression and interaction of clock genes, so too do rhythms at the SCN tissue level depend on sequential activation of local nodes. We hypothesize that individual neurons are organized into nodes that are themselves sequentially activated across the volume of the SCN in a cycle that repeats on a daily basis. We further propose that robustness is expressed in the ability of the SCN to sustain rhythmicity over a wide range of internal and external conditions, and that this reflects plasticity of the underlying nodes and circuits. Resilience is expressed in the ability of SCN cells to oscillate and to sustain activity-related rhythms at the behavioral level. Importantly, other aspects of pacemaker function remain to be examined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.