ArticleGenome medicine2009
Bridging the gap between systems biology and medicine.
Article in Genome medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Repositioning Natural Products in Modern Drug Discovery: Technological Innovation, Systems Pharmacology, and Pathological Validation.International journal of molecular sciences · 2026Review
- Cross-disciplinary methodologies for whole-person research - insights from EMPOWER2024.Npj imaging · 2026Article
- Precision cardiovascular medicine: shifting the innovation paradigm.Frontiers in science · 2025Article
- Lactation physiokinetics-using advances in technology for a fresh perspective on human milk transfer.Frontiers in pediatrics · 2023Article
- An Early Stage Researcher's Primer on Systems Medicine Terminology.Network and systems medicine · 2021Review
- Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma.PLoS computational biology · 2019Article
- Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine.Synthese · 2018Article
- Applying systems biology to biomedical research and health care: a précising definition of systems medicine.BMC health services research · 2017Article
- Systems Medicine-Complexity Within, Simplicity Without.Journal of healthcare informatics research · 2017Article
- Bridging the gap between clinicians and systems biologists: from network biology to translational biomedical research.Journal of translational medicine · 2016Review
- The new holism: P4 systems medicine and the medicalization of health and life itself.Medicine, health care, and philosophy · 2016Article
- Systems biology approaches to adverse drug effects: the example of cardio-oncology.Nature reviews. Clinical oncology · 2015Review
- Systems Medicine 2.0: potential benefits of combining electronic health care records with systems science models.Journal of medical Internet research · 2015Article
- MicroRNA signatures as biomarkers and therapeutic target for CNS embryonal tumors: the pros and the cons.International journal of molecular sciences · 2014Review
- Computational Horizons In Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Repositories forProceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation : the CHIC Project Workshop (IARWISOCI) : Athens, Greece, 3-4 November 2014. International Advanced Research Workshop on... · 2014Article
- Accelerating translational research by clinically driven development of an informatics platform--a case study.PloS one · 2014Article
- 21st century natural product research and drug development and traditional medicines.Natural product reports · 2013Review
- Prediction of heart rate response to conclusion of the spontaneous breathing trial by fluctuation dissipation theory.Physical biology · 2013Article
- Network medicine: linking disorders.Human genetics · 2012Review
- Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now becoming apparent. As these gaps are better defined, the new discipline of systems medicine is emerging as a translational extension of systems biology. How is systems medicine defined? What are relevant ontologies for systems medicine? What are the key theoretic and methodologic challenges facing computational disease modeling? How are inaccurate and incomplete data, and uncertain biologic knowledge best synthesized in useful computational models? Does network analysis provide clinically useful insight? We discuss the outstanding difficulties in translating a rapidly growing body of data into knowledge usable at the bedside. Although core-specific challenges are best met by specialized groups, it appears fundamental that such efforts should be guided by a roadmap for systems medicine drafted by a coalition of scientists from the clinical, experimental, computational, and theoretic domains.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.