ArticleEnvironmental health : a global access science source2009
Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up.
Article in Environmental health : a global access science source, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of cancer risks in relation to environmental waste incinerator emissions: a meta-analysis of case-control and cohort studies.Epidemiology and health · 2022Pooled it
- Association between dioxin and cancer incidence and mortality: a meta-analysis.Scientific reports · 2016Pooled it
- Environmental exposures and multiple myeloma risk: A contemporary review of epidemiologic associations and mechanistic plausibility.Blood reviews · 2026Review
- [Health surveillance after the Samarco dam disaster: evaluation of standards of care in chronic diseases and mental disorders (2008-2023)].Cadernos de saude publica · 2026Article
- Dioxins and the One Health Paradigm: An Interdisciplinary Challenge in Environmental Toxicology.Toxics · 2025Review
- Ambient dioxin exposure and incidence of lymphoid malignancies in large prospective US cohorts of female nurses.Journal of hazardous materials · 2025Article
- Agent Orange and head and neck cancer: A systematic review and meta-analysis.World journal of otorhinolaryngology - head and neck surgery · 2025Review
- High Expression of AhR and Environmental Pollution as AhR-Linked Ligands Impact on Oncogenic Signaling Pathways in Western Patients with Gastric Cancer-A Pilot Study.Biomedicines · 2024Article
- Mortality and cancer incidence in a population exposed to TCDD after the Seveso, Italy, accident (1976-2013).Occupational and environmental medicine · 2024Article
- Residential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study.Environment international · 2024Article
- A new approach to study stochastic epigenetic mutations in sperm methylome of Vietnam war veterans directly exposed to Agent Orange.Environmental epigenetics · 2024Article
- Residential proximity to dioxin emissions and risk of breast cancer in the sister study cohort.Environmental research · 2023Article
- Association between meat, fish, and fatty acid intake and incidence of acute myeloid leukemia and myelodysplastic syndrome: the Japan Public Health Center-based Prospective Study.Environmental health and preventive medicine · 2023Article
- The intestine: A highly dynamic microenvironment for IgA plasma cells.Frontiers in immunology · 2023Review
- Review
- The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea.International journal of environmental research and public health · 2022Article
- Research on the Relationship between Exposure to Dioxins and Cancer Incidence in Vietnam.Toxics · 2022Review
- Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.Biomolecules · 2022Review
- Emissions of dioxins and dioxin-like compounds and incidence of hepatocellular carcinoma in the United States.Environmental research · 2022Article
- Article
1 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
backgroundThe Seveso, Italy accident in 1976 caused the contamination of a large population by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Possible long-term effects have been examined through mortality and cancer incidence studies. We have updated the cancer incidence study which now covers the period 1977-96.
methodsThe study population includes subjects resident at the time of the accident in three contaminated zones with decreasing TCDD soil levels (zone A, very high; zone B, high; zone R, low) and in a surrounding non-contaminated reference territory. Gender-, age-, and period-adjusted rate ratios (RR) and 95% confidence intervals (95% CI) were calculated by using Poisson regression for subjects aged 0-74 years.
resultsAll cancer incidence did not differ from expectations in any of the contaminated zones. An excess of lymphatic and hematopoietic tissue neoplasms was observed in zones A (four cases; RR, 1.39; 95% CI, 0.52-3.71) and B (29 cases; RR, 1.56; 95% CI, 1.07-2.27) consistent with the findings of the concurrent mortality study. An increased risk of breast cancer was detected in zone A females after 15 years since the accident (five cases, RR, 2.57; 95% CI, 1.07-6.20). No cases of soft tissue sarcomas occurred in the most exposed zones (A and B, 1.17 expected). No cancer cases were observed among subjects diagnosed with chloracne early after the accident.
conclusionThe extension of the Seveso cancer incidence study confirmed an excess risk of lymphatic and hematopoietic tissue neoplasms in the most exposed zones. No clear pattern by time since the accident and zones was evident partly because of the low number of cases. The elevated risk of breast cancer in zone A females after 15 years since the accident deserves further and thorough investigation. The follow-up is continuing in order to cover the long time period (even decades) usually elapsing from exposure to carcinogenic chemicals and disease occurrence.
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