ReviewImmunological reviews2009
Formation of STIM and Orai complexes: puncta and distal caps.
Review in Immunological reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Article
- Article
- Improper Remodeling of Organelles Deputed to CaInternational journal of molecular sciences · 2021Review
- Impairment of mitochondrial unfolded protein response contribute to resistance declination of HThe Kaohsiung journal of medical sciences · 2020Article
- Article
- CaFrontiers in oncology · 2017Review
- Seasonal immunoregulation in a naturally-occurring vertebrate.BMC genomics · 2016Article
- The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.Nature immunology · 2014Article
- Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entry.Biophysical journal · 2014Article
- Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.Journal of cell science · 2013Article
- Ca(2+) signaling in T-cell subsets with a focus on the role of cav1 channels: possible implications in therapeutics.Frontiers in immunology · 2013Article
- Differences in cap formation between invasive Entamoeba histolytica and non-invasive Entamoeba dispar.Parasitology research · 2012Article
- Chloride in airway smooth muscle: the ignored anion no longer?American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Endoplasmic reticulum calcium pumps and cancer cell differentiation.Biomolecules · 2012Article
- Murine Tim-1 is excluded from the immunological synapse.F1000Research · 2012Article
- Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.Small GTPases · 2011Article
- Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is located in the endoplasmic reticulum, and Orai1, a protein that forms a calcium channel in the plasma membrane, interact and give rise to store-operated calcium entry. Pharmacological depletion of calcium stores leads to the formation of clusters containing STIM and Orai that appear to be sites for calcium influx. Similar puncta are also produced in response to physiological stimuli in immune cells. In T cells engaged with antigen-presenting cells, clusters containing STIM and Orai accumulate at the immunological synapse. We recently discovered that in activated T cells, STIM1 and Orai1 also accumulate in cap-like structures opposite the immune synapse at the distal pole of the cell. Both caps and puncta are long-lived stable structures containing STIM1 and Orai1 in close proximity. The function of puncta as sites of calcium influx is clear. We speculate that the caps may provide a secondary site of calcium entry. Alternatively, they may serve as a source of preformed channel complexes that move to new immune synapses as T cells repeatedly engage antigen-presenting cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.