ReviewJournal of cellular and molecular medicine2010
Monocyte transplantation for neural and cardiovascular ischemia repair.
Review in Journal of cellular and molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells.Stem cells (Dayton, Ohio) · 2017Trial
- Adipose-Derived Stem Cells to Treat Ischemic Diseases: The Case of Peripheral Artery Disease.International journal of molecular sciences · 2023Review
- Macrophage/microglia polarization for the treatment of diabetic retinopathy.Frontiers in endocrinology · 2023Review
- Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel.Gels (Basel, Switzerland) · 2022Article
- Potential role of IGF-1/GLP-1 signaling activation in intracerebral hemorrhage.Current research in neurobiology · 2022Review
- Article
- Human monocytes subjected to ischaemia/reperfusion inhibit angiogenesis and wound healing in vitro.Cell proliferation · 2020Article
- Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke.Frontiers in neuroscience · 2019Review
- Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro.Stem cells international · 2019Article
- An integrated microfluidic platform for size-selective single-cell trapping of monocytes from blood.Biomicrofluidics · 2018Article
- Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy.Investigative ophthalmology & visual science · 2017Article
- A cord blood monocyte-derived cell therapy product accelerates brain remyelination.JCI insight · 2016Article
- Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat.Molecular and cellular neurosciences · 2014Article
- The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions.Stem cells and development · 2014Article
- Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function.Journal of leukocyte biology · 2014Article
- In vivo detection of macrophage recruitment in hind-limb ischemia using a targeted near-infrared fluorophore.PloS one · 2014Article
- MCP-1-induced protein promotes endothelial-like and angiogenic properties in human bone marrow monocytic cells.The Journal of pharmacology and experimental therapeutics · 2013Article
- Anticonvulsant activity of bone marrow cells in electroconvulsive seizures in mice.BMC neuroscience · 2013Article
- Rescuing the neonatal brain from hypoxic injury with autologous cord blood.Bone marrow transplantation · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. In terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. In addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their pro-angiogenic ability. In this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.