ArticleFrontiers in molecular neuroscience2009
Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions.
Article in Frontiers in molecular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Neuronal gain modulability is determined by dendritic morphology: A computational optogenetic study.PLoS computational biology · 2018Article
- Optogenetic versus Electrical Stimulation of Human Cardiomyocytes: Modeling Insights.Biophysical journal · 2015Article
- How might novel technologies such as optogenetics lead to better treatments in epilepsy?Advances in experimental medicine and biology · 2014Review
- Optical control of neuronal excitation and inhibition using a single opsin protein, ChR2.Scientific reports · 2013Article
- Characterization of a highly efficient blue-shifted channelrhodopsin from the marine alga Platymonas subcordiformis.The Journal of biological chemistry · 2013Article
- Optogenetic stimulation effectively enhances intrinsically generated network synchrony.Frontiers in neural circuits · 2013Article
- Genetically encoded molecular tools for light-driven silencing of targeted neurons.Progress in brain research · 2012Review
- Optogenetic tools for analyzing the neural circuits of behavior.Trends in cognitive sciences · 2011Review
- A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins.Nature methods · 2011Article
- Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans.Nature communications · 2011Article
- Remote control of neuronal signaling.Pharmacological reviews · 2011Review
- Synthetic physiology strategies for adapting tools from nature for genetically targeted control of fast biological processes.Methods in enzymology · 2011Article
- Frontiers in molecular neuroscience - résumé and perspective.Frontiers in molecular neuroscience · 2011Article
- Article
- Optogenetic deconstruction of sleep-wake circuitry in the brain.Frontiers in molecular neuroscience · 2010Article
- Genetic techniques and circuit analysis.Frontiers in molecular neuroscience · 2010Article
- Studying Cerebellar Circuits by Remote Control of Selected Neuronal Types with GABA(A) Receptors.Frontiers in molecular neuroscience · 2009Article
- Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila.Frontiers in molecular neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Synchronous neural activity occurs throughout the brain in association with normal and pathological brain functions. Despite theoretical work exploring how such neural coordination might facilitate neural computation and be corrupted in disease states, it has proven difficult to test experimentally the causal role of synchrony in such phenomena. Attempts to manipulate neural synchrony often alter other features of neural activity such as firing rate. Here we evaluate a single gene which encodes for the blue-light gated cation channel channelrhodopsin-2 and the yellow-light driven chloride pump halorhodopsin from Natronobacterium pharaonis, linked by a 'self-cleaving' 2A peptide. This fusion enables proportional expression of both opsins, sensitizing neurons to being bi-directionally controlled with blue and yellow light, facilitating proportional optical spike insertion and deletion upon delivery of trains of precisely-timed blue and yellow light pulses. Such approaches may enable more detailed explorations of the causal role of specific features of the neural code.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.