ArticlePloS one2009
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 193 citations in OpenAlex.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Photoperiodism, testosterone and adult neurogenesis in canaries (Serinus canaria).Journal of neuroendocrinology · 2025Review
- Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodents.Frontiers in immunology · 2025Review
- Effect of microwave radiation on adult neurogenesis and behavior of prenatally exposed rats.IBRO neuroscience reports · 2024Article
- A lack of drebrin causes olfactory impairment.Brain and behavior · 2024Article
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Single-cell RNA sequencing of aging neural progenitors reveals loss of excitatory neuron potential and a population with transcriptional immune response.Frontiers in neuroscience · 2024Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries.Scientific reports · 2023Article
- Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs.Stem cell reports · 2023Article
- Olfactory neurogenesis and its role in fear memory modulation.Frontiers in behavioral neuroscience · 2023Review
- Radiotherapy Side Effects: Comprehensive Proteomic Study Unraveled Neural Stem Cell Degenerative Differentiation upon Ionizing Radiation.Biomolecules · 2022Article
- Article
- Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- In the pursuit of new social neurons. Neurogenesis and social behavior in mice: A systematic review.Frontiers in cell and developmental biology · 2022Review
- Scent of stem cells: How can neurogenesis make us smell better?Frontiers in neuroscience · 2022Article
- Metformin pretreatment rescues olfactory memory associated with subependymal zone neurogenesis in a juvenile model of cranial irradiation.Cell reports. Medicine · 2021Article
- Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.Stem cell reports · 2021Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Context-dependent plasticity of adult-born neurons regulated by cortical feedback.Science advances · 2020Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons, granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the rostral migratory stream toward the OB. Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear. METHODOLOGY/PRINCIPAL
findingsIn this study, we irradiated adult mice to impair constitutive OB neurogenesis, and explored the functional impacts of this irradiation on the sense of smell. We found that focal irradiation of the SVZ greatly decreased the rate of production of new OB neurons, leaving other brain areas intact. This effect persisted for up to seven months after exposure to 15 Gray. Despite this robust impairment, the thresholds for detecting pure odorant molecules and short-term olfactory memory were not affected by irradiation. Similarly, the ability to distinguish between odorant molecules and the odorant-guided social behavior of irradiated mice were not affected by the decrease in the number of new neurons. Only long-term olfactory memory was found to be sensitive to SVZ irradiation. CONCLUSION/SIGNIFICANCE: These findings suggest that the continuous production of adult-generated neurons is involved in consolidating or restituting long-lasting olfactory traces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.