ArticlePloS one2009
Enterocyte shedding and epithelial lining repair following ischemia of the human small intestine attenuate inflammation.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 67 citations in OpenAlex.
- Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium.Cellular and molecular gastroenterology and hepatology · 2019Trial
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- Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota.Journal of bacteriology · 2025Review
- Brief Disruption of Circadian Rhythms Alters Intestinal Barrier Integrity and Modulates DSS-Induced Colitis Severity in Mice.Inflammation · 2025Article
- Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury.Clinical and translational medicine · 2025Review
- Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.Frontiers in immunology · 2023Article
- Article
- Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa.Inflammatory intestinal diseases · 2021Article
- Article
- Involvement of hyaluronan in the adaptive changes of the rat small intestine neuromuscular function after ischemia/reperfusion injury.Scientific reports · 2020Article
- Control and dysregulation of redox signalling in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2019Review
- Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.International journal of molecular medicine · 2018Article
- Neutrophils as Components of Mucosal Homeostasis.Cellular and molecular gastroenterology and hepatology · 2017Review
- Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.Nature communications · 2017Article
- Tissue metabolism and host-microbial interactions in the intestinal mucosa.Free radical biology & medicine · 2017Review
- The digestive tract as the origin of systemic inflammation.Critical care (London, England) · 2016Review
- Neutrophils and the inflammatory tissue microenvironment in the mucosa.Immunological reviews · 2016Review
- Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.The Journal of physiology · 2016Article
- Hypoxia and Mucosal Inflammation.Annual review of pathology · 2016Review
- Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, we observed that small-intestinal ischemia and reperfusion was found to entail a rapid loss of apoptotic and necrotic cells. This study was conducted to investigate whether the observed shedding of ischemically damaged epithelial cells affects IR induced inflammation in the human small gut. METHODS AND
findingsUsing a newly developed IR model of the human small intestine, the inflammatory response was studied on cellular, protein and mRNA level. Thirty patients were consecutively included. Part of the jejunum was subjected to 30 minutes of ischemia and variable reperfusion periods (mean reperfusion time 120 (+/-11) minutes). Ethical approval and informed consent were obtained. Increased plasma intestinal fatty acid binding protein (I-FABP) levels indicated loss in epithelial cell integrity in response to ischemia and reperfusion (p<0.001 vs healthy). HIF-1alpha gene expression doubled (p = 0.02) and C3 gene expression increased 4-fold (p = 0.01) over the course of IR. Gut barrier failure, assessed as LPS concentration in small bowel venous effluent blood, was not observed (p = 0.18). Additionally, mRNA expression of HO-1, IL-6, IL-8 did not alter. No increased expression of endothelial adhesion molecules, TNFalpha release, increased numbers of inflammatory cells (p = 0.71) or complement activation, assessed as activated C3 (p = 0.14), were detected in the reperfused tissue.
conclusionsIn the human small intestine, thirty minutes of ischemia followed by up to 4 hours of reperfusion, does not seem to lead to an explicit inflammatory response. This may be explained by a unique mechanism of shedding of damaged enterocytes, reported for the first time by our group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.