ArticlePLoS biology2009
Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- COPI Vesicle and Tubule Formation at the Golgi Complex.Sub-cellular biochemistry · 2026Review
- Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.Molecular neurodegeneration · 2024Article
- The Diffusion Model of Intra-Golgi Transport Has Limited Power.International journal of molecular sciences · 2023Article
- Deficiency in coatomer complex I causes aberrant activation of STING signalling.Nature communications · 2022Article
- Genetically encoded fluorescent tools: Shining a little light on ER-to-Golgi transport.Free radical biology & medicine · 2022Review
- Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase AFrontiers in cell and developmental biology · 2022Article
- An Update on the Key Factors Required for Plant Golgi Structure Maintenance.Frontiers in plant science · 2022Review
- CaFaculty reviews · 2022Review
- Lipid Droplets, Phospholipase ABiomedicines · 2021Review
- The Golgi complex: a hub of the secretory pathway.BMB reports · 2021Review
- The Cytosolic Phospholipase ABiomolecules · 2020Article
- Endocytosis and Exocytosis inFrontiers in cellular and infection microbiology · 2020Article
- Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase AeLife · 2019Article
- Cellular Protein Kinase D Modulators Play a Role during Multiple Steps of Herpes Simplex Virus 1 Egress.Journal of virology · 2018Article
- ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness.Scientific reports · 2017Article
- Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ.Nature communications · 2016Article
- Article
- Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic.Cellular and molecular life sciences : CMLS · 2016Article
- Cytosolic phospholipase A₂: physiological function and role in disease.Journal of lipid research · 2015Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The organization of intra-Golgi trafficking and the nature of the transport intermediates involved (e.g., vesicles, tubules, or tubular continuities) remain incompletely understood. It was recently shown that successive cisternae in the Golgi stack are interconnected by membrane tubules that form during the arrival of transport carriers from the endoplasmic reticulum. Here, we examine the mechanisms of generation and the function of these tubules. In principle, tubule formation might depend on several protein- and/or lipid-based mechanisms. Among the latter, we have studied the phospholipase A(2) (PLA(2))-mediated generation of wedge-shaped lysolipids, with the resulting local positive membrane curvature. We show that the arrival of cargo at the Golgi complex induces the recruitment of Group IVA Ca(2+)-dependent, cytosolic PLA(2) (cPLA(2)alpha) onto the Golgi complex itself, and that this cPLA(2)alpha is required for the formation of the traffic-dependent intercisternal tubules and for intra-Golgi transport. In contrast, silencing of cPLA(2)alpha has no inhibitory effects on peri-Golgi vesicles. These findings identify cPLA(2)alpha as the first component of the machinery that is responsible for the formation of intercisternal tubular continuities and support a role for these continuities in transport through the Golgi complex.
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