ArticleThe EMBO journal1990
Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification.Hereditas · 2024Article
- Seeing is believing: the Bicoid protein reveals its path.Hereditas · 2018Article
- A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites.PloS one · 2011Article
- Selection intensity against deleterious mutations in RNA secondary structures and rate of compensatory nucleotide substitutions.Genetics · 2001Article
- Comparative sequence analysis and patterns of covariation in RNA secondary structures.Genetics · 2000Article
- Molecular cloning and characterization of a transcription factor for the copia retrotransposon with homology to the BTB-containing lola neurogenic factor.Molecular and cellular biology · 1997Article
- Sequence and evolution of the Drosophila pseudoobscura glycerol-3-phosphate dehydrogenase locus.Journal of molecular evolution · 1995Article
- exl protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Conservation and function of the transcriptional regulatory protein Runt.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Transdifferentiation of chicken embryonic cells into muscle cells by the 3' untranslated region of muscle tropomyosin.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Molecular characterization of the zerknüllt region of the Antennapedia complex of D. subobscura.Chromosoma · 1995Article
- Components acting in localization of bicoid mRNA are conserved among Drosophila species.Genetics · 1994Article
- Genetics of reproductive isolation in the Drosophila simulans clade: complex epistasis underlying hybrid male sterility.Genetics · 1994Article
- Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila.Genetics · 1994Article
- Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome.Genetics · 1993Article
- Article
- Nucleotide divergence of the rp49 gene region between Drosophila melanogaster and two species of the Obscura group of Drosophila.Journal of molecular evolution · 1993Article
- Gypsy homologous sequences in Drosophila subobscura (gypsyDS).Journal of molecular evolution · 1993Article
- A comparison of transplantable bicoid activity and partial bicoid homeobox sequences in several Drosophila and blowfly species (Calliphoridae).Roux's archives of developmental biology : the official organ of the EDBO · 1993Article
- Comparative studies of Drosophila Antennapedia genes.Genetics · 1992Article
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2 authors at 1 institution in 1 country.
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Abstract
The specification of anterior positional information during Drosophila embryogenesis is largely dependent upon the function of the maternal-effect gene bicoid (bcd). Two aspects of bcd function are particularly striking. First, the bcd protein product forms a gradient during early embryogenesis, which regulates the transcription of at least one zygotic segmentation gene, hunchback, in a concentration dependent manner. Secondly, formation of the bcd protein gradient is dependent upon the specific localization of bcd mRNAs at the anterior end of the oocyte/embryo during oogenesis, a process which requires a cis-acting 625 nucleotide sequence within the 3' untranslated region of the bcd mRNA. We have cloned and sequenced the bcd gene from Drosophila pseudoobscura as a tool in identifying important functional domains within this transcription unit. DNA sequence comparisons reveal: (i) varying degrees of amino acid sequence conservation among the proposed functional domains of the bcd protein, (ii) the conservation of potential RNA secondary structures within the bcd mRNA localization element, and (iii) the maintenance of a short open reading frame within the 5' untranslated leader that may play a role in translational regulation. Finally, the D.pseudoobscura bcd gene partially rescues the phenotype of a bcd- mutation when placed into the D.melanogaster genome by germline transformation. The lack of full phenotypic rescue can be explained in part by the observed improper localization of the D.pseudoobscura bcd mRNA when expressed in D.melanogaster.
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