ArticleGenome research2009
Two-parameter characterization of chromosome-scale recombination rate.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- GViNC: an innovative framework for genome graph comparison reveals hidden patterns in the genetic diversity of human populations.NAR genomics and bioinformatics · 2025Article
- Mapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain.Frontiers in genetics · 2019Article
- Accurate Genotype Imputation in Multiparental Populations from Low-Coverage Sequence.Genetics · 2018Article
- Low recombination rates in sexual species and sex-asex transitions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Variation of the meiotic recombination landscape and properties over a broad evolutionary distance in yeasts.PLoS genetics · 2017Article
- Evolutionary mysteries in meiosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Genome-wide variation in recombination rate in Eucalyptus.BMC genomics · 2016Article
- Biased gene conversion and GC-content evolution in the coding sequences of reptiles and vertebrates.Genome biology and evolution · 2014Article
- Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions.Genetic epidemiology · 2014Article
- Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici.Molecular plant-microbe interactions : MPMI · 2012Article
- An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group.Human genetics · 2012Article
- Genome-wide crossover distribution in Arabidopsis thaliana meiosis reveals sex-specific patterns along chromosomes.PLoS genetics · 2011Article
- Article
- Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps.Genome research · 2011Article
- Substitution patterns are under different influences in primates and rodents.Genome biology and evolution · 2011Article
- Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.Genome research · 2010Article
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2 authors.
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Abstract
The genome-wide recombination rate (RR) of a species is often described by one parameter, the ratio between total genetic map length (G) and physical map length (P), measured in centimorgans per megabase (cM/Mb). The value of this parameter varies greatly between species, but the cause for these differences is not entirely clear. A constraining factor of overall RR in a species, which may cause increased RR for smaller chromosomes, is the requirement of at least one chiasma per chromosome (or chromosome arm) per meiosis. In the present study, we quantify the relative excess of recombination events on smaller chromosomes by a linear regression model, which relates the genetic length of chromosomes to their physical length. We find for several species that the two-parameter regression, G = G(0) + k x P , provides a better characterization of the relationship between genetic and physical map length than the one-parameter regression that runs through the origin. A nonzero intercept (G(0)) indicates a relative excess of recombination on smaller chromosomes in a genome. Given G(0), the parameter k predicts the increase of genetic map length over the increase of physical map length. The observed values of G(0) have a similar magnitude for diverse species, whereas k varies by two orders of magnitude. The implications of this strategy for the genetic maps of human, mouse, rat, chicken, honeybee, worm, and yeast are discussed.
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