ArticleParasitology international2009
C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.
Article in Parasitology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
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- Transcriptome Analysis ofPlants (Basel, Switzerland) · 2024Article
- Editorial: Insights into glyco-parasitology.Frontiers in molecular biosciences · 2024Article
- Immune Regulatory Roles of Cells Expressing Taste Signaling Elements in Nongustatory Tissues.Handbook of experimental pharmacology · 2022Article
- Lectin-Mediated Bacterial Modulation by the Intestinal NematodeInternational journal of molecular sciences · 2021Article
- Review
- The Gastrointestinal HelminthFrontiers in immunology · 2020Article
- A Meloidogyne graminicola C-type lectin, Mg01965, is secreted into the host apoplast to suppress plant defence and promote parasitism.Molecular plant pathology · 2019Article
- Knockdown of a mucin-like gene in Meloidogyne incognita (Nematoda) decreases attachment of endospores of Pasteuria penetrans to the infective juveniles and reduces nematode fecundity.Molecular plant pathology · 2018Article
- Parasitic Nematodes Exert Antimicrobial Activity and Benefit From Microbiota-Driven Support for Host Immune Regulation.Frontiers in immunology · 2018Article
- The Intestinal RoundwormFrontiers in cellular and infection microbiology · 2018Article
- The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search.International journal of molecular sciences · 2017Article
- Meloidogyne graminicola: a major threat to rice agriculture.Molecular plant pathology · 2017Review
- Reciprocal Interactions between Nematodes and Their Microbial Environments.Frontiers in cellular and infection microbiology · 2017Review
- The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates.Parasites & vectors · 2016Article
- Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.Nature communications · 2014Article
- Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.Mucosal immunology · 2014Article
- Identification of candidate effector genes in the transcriptome of the rice root knot nematode Meloidogyne graminicola.Molecular plant pathology · 2013Article
- Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.European journal of immunology · 2012Article
- Immune modulation and modulators in Heligmosomoides polygyrus infection.Experimental parasitology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The C-type lectin superfamily is highly represented in all metazoan phyla so far studied. Many members of this superfamily are important in innate immune defences against infection, while others serve key developmental and structural roles. Within the superfamily, many proteins contain multiple canonical carbohydrate-recognition domains (CRDs), together with additional non-lectin domains. In this report, we have studied two gastrointestinal nematode parasites which are widely used in experimental rodent systems, Heligmosomoides polygyrus and Nippostrongylus brasiliensis. From cDNA libraries, we have isolated 3 new C-type lectins from these species; all are single-CRD proteins with short additional N-terminal domains. The predicted Hp-CTL-1 protein contains 156 aa, Nb-CTL-1 191 aa and Nb-CTL-2 183 aa; all encode predicted signal peptides, as well as key conserved sequence motifs characteristic of the CTL superfamily. These lectins are most similar to C. elegans CLEC-48, 49 and 50, as well as to the lectin domains of mammalian immune system proteins CD23 and CD206. RT-PCR showed that these H. polygyrus and N. brasiliensis genes are primarily expressed in the gut-dwelling adult stages, although Nb-CTL-2 transcripts are also prominent in the free-living infective larval (L3) stage. Polyclonal antibodies raised to Hp-CTL-1 and Nb-CTL-1 reacted to both proteins by ELISA, and in Western blot analysis recognised a 15-kDa band in secreted proteins of adult N. brasiliensis (NES) and a 19-kDa band in H. polygyrus ES (HES). Anti-CTL-1 antibody also bound strongly to the cuticle of adult H. polygyrus. Hence, live parasites release C-type lectins homologous to some key receptors of the mammalian host immune system, raising the possibility that these products interfere in some manner with immunological recognition or effector function.
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Registered trials
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