ArticleDevelopmental biology2009
Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
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- Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells.PLoS genetics · 2025Article
- Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche.Nature communications · 2022Article
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- High-precision targeting workflow for volume electron microscopy.The Journal of cell biology · 2021Article
- Generation of extracellular morphogen gradients: the case for diffusion.Nature reviews. Genetics · 2021Review
- Cytoneme-mediated signaling essential for tumorigenesis.PLoS genetics · 2019Article
- Disentangling geometrical, viscoelastic and hyperelastic effects in force-displacement relationships of folded biological tissues.The European physical journal. E, Soft matter · 2019Article
- The Air Sac Primordium ofInternational journal of molecular sciences · 2018Review
- Development and Function of theGenetics · 2018Review
- Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans.Nature protocols · 2017Article
- Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis.Developmental biology · 2017Article
- Article
- FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2.Scientific reports · 2015Article
- A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.FEBS letters · 2015Article
- Article
- Building from the Ground up: Basement Membranes in Drosophila Development.Current topics in membranes · 2015Review
- Border patrol: insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila Dorsal Air Sac Primordium (ASP) is a tracheal tube that grows toward Branchless FGF-expressing cells in the wing imaginal disc. We show that the ASP arises from a tracheal branch that invades the basal lamina of the disc to juxtapose directly with disc cells. We examined the role of matrix metalloproteases (Mmps), and found that reducing Mmp2 activity perturbed disc-trachea association, altered peritracheal distributions of collagen IV and Perlecan, misregulated ASP growth, and abrogated development of the dorsal air sacs. Whereas the function of the membrane-tethered Mmp2 in the ASP is non-cell autonomous we find that it may have distinct tissue-specific roles in the ASP and disc. These findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.