Evidence map›Paper›PMID 19751666›Full record

ArticleBiophysical journal2009

New insights into BAR domain-induced membrane remodeling.

Gary S Ayton, Edward Lyman, Vinod Krishna, Richard D Swenson, Carsten Mim, Vinzenz M Unger, Gregory A Voth

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Article
  3. Modeling membrane reshaping driven by dynamic protein assemblies.Current opinion in structural biology · 2023
    Review
  4. Bottom-up Coarse-Graining: Principles and Perspectives.Journal of chemical theory and computation · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales.Journal of physics. Condensed matter : an Institute of Physics journal · 2018
    Article
  14. Article
  15. Systems biology of cellular membranes: a convergence with biophysics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017
    Review
  16. Article
  17. The mesoscopic membrane with proteins (MesM-P) model.The Journal of chemical physics · 2017
    Article
  18. Article
  19. Review
  20. Physical basis of some membrane shaping mechanisms.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gary S AytonCenter for Biophysical Modeling and Simulation, University of Utah, Salt Lake City, Utah, USA.
Edward Lyman
Vinod Krishna
Richard D Swenson
Carsten Mim
Vinzenz M Unger
Gregory A Voth
University of Utah · USYale University · US

Funding

New Method for Biomembrane SimulationsR01GM063796 · NIGMS · UNIVERSITY OF UTAH · PI VOTH, GREGORY A. · 2001 to 2025
$6.3M
Structural Biology of Presynaptic ScaffoldsR21DA024101 · NIDA · YALE UNIVERSITY · PI UNGER, VINZENZ · 2008 to 2009
$331k
NIDA NIH HHS R21 DA024101NIDA NIH HHS R21-DA024101NIGMS NIH HHS R01 GM063796NIGMS NIH HHS R01-GM063796
6 · The paper itself

Abstract

Mesoscopic simulations and electron microscopy of N-BAR domain-induced liposome remodeling are used to characterize the process of liposome tubulation and vesiculation. The overall process of membrane remodeling is found to involve complex couplings among the N-BAR protein density, the degree of N-BAR oligomerization, and the membrane density. A comparison of complex remodeled liposome structures from mesoscopic simulations with those measured by electron microscopy experiments suggests that the process of membrane remodeling can be described via an appropriate mesoscopic free energy framework. Liposome remodeling more representative of F-BAR domains is also presented within the mesoscopic simulation framework.

Indexed as

AcyltransferasesAnimalsElasticityLiposomesMicroscopy, ElectronModels, BiologicalNerve Tissue ProteinsProtein Structure, TertiaryRats2-acylglycerophosphate acyltransferaseAcyltransferasesamphiphysinLiposomesNerve Tissue Proteins

Identifiers

PMID19751666
PMCPMC2749773
OpenAlexW2032113234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.