ArticleJournal of neurotrauma2010
Expression of protein phosphatase 2B (calcineurin) subunit A isoforms in rat hippocampus after traumatic brain injury.
Article in Journal of neurotrauma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats.Molecular neurobiology · 2024Article
- Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults.Biomolecules · 2024Review
- Traumatic Brain Injury Temporal Proteome Guides KCC2-Targeted Therapy.Journal of neurotrauma · 2019Article
- Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets.Frontiers in cellular neuroscience · 2019Review
- Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.Journal of neurotrauma · 2017Article
- Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury.Experimental neurology · 2016Article
- Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.Frontiers in neurology · 2016Article
- Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury.Neural regeneration research · 2015Article
- Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development.Journal of neurotrauma · 2014Review
- Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus.Brain research · 2014Article
- Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics.Journal of neurotrauma · 2013Article
- Differential effects of FK506 on structural and functional axonal deficits after diffuse brain injury in the immature rat.Journal of neuropathology and experimental neurology · 2012Article
- Post-traumatic hypoxia exacerbates neuronal cell death in the hippocampus.Journal of neurotrauma · 2012Article
- The combination of either tempol or FK506 with delayed hypothermia: implications for traumatically induced microvascular and axonal protection.Journal of neurotrauma · 2011Article
- Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury.Brain research · 2010Article
- Targeting Dopamine in Acute Traumatic Brain Injury.The open drug discovery journal · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Calcineurin (CaN) is a calcium/calmodulin-dependent phosphatase directly activated by calcium as a result of neuronal activation that is important for neuronal function. CaN subunit isoforms are implicated in long-term potentiation (LTP), long-term depression (LTD), and structural plasticity. CaN inhibitors are also beneficial to cognitive outcomes in animal models of traumatic brain injury (TBI). There are known changes in the CaN A (CnA) subunit following fluid percussion injury (FPI). The CnA subunit has two isoforms: CnAalpha and CnAbeta. The effect of moderate controlled cortical impact (CCI) on distribution of CnA isoforms was examined at 2 h and 2 weeks post-injury. CnA distribution was assayed by immunohistochemistry and graded for non-parametric analysis. Acutely CnA isoforms showed reduced immunoreactivity in stratum radiatum processes of the ipsilateral CA1 and CA1-2. There was also a significant alteration in the immunoreactivity of both CnA isoforms in the ipsilateral dentate gyrus, predominantly within the hidden blade. Alterations in CnA isoform regional distribution within the CA1, CA1-2, and dentate gyrus may have significant implications for persistent hippocampal dysfunction following TBI, including dysfunction in hippocampal plasticity. Understanding alterations in CnA isoform distribution may help improve the targeting of current therapeutic interventions and/or the development of new treatments for TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.