ArticleNucleic acids research1990
Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 49 citations in OpenAlex.
- Isolation and chromosomal localization of a human ATP-regulated potassium channel.Human genetics · 1995Article
- New localization of NCAM, proximal to DRD2 at chromosome 11q23.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Schizophrenia-associated chromosome 11q21 translocation: identification of flanking markers and development of chromosome 11q fragment hybrids as cloning and mapping resources.American journal of human genetics · 1993Article
- A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23.Journal of medical genetics · 1993Article
- Cloning of a candidate gene for ataxia-telangiectasia group D.American journal of human genetics · 1992Article
- Ataxia telangiectasia genes and predisposition to leukaemia, lymphoma and breast cancer.British journal of cancer · 1992Review
- Ataxia-telangiectasia: linkage evidence for genetic heterogeneity.American journal of human genetics · 1992Article
- Ataxia-telangiectasia: linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome.Human genetics · 1992Article
- Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.American journal of human genetics · 1991Article
- Functional complementation of ataxia-telangiectasia group D (AT-D) cells by microcell-mediated chromosome transfer and mapping of the AT-D locus to the region 11q22-23.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.American journal of human genetics · 1990Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Using pulsed-field gel electrophoresis, and a range of different enzyme digests, we have established that both markers of each of the pairs CJ52.208/YNB3.12, NCAM/DRD2, and STMY/CJ52.75, on chromosome 11q22-23, show physical linkage on a single DNA fragment. We have also shown, using genetic linkage and haplotype analyses, that these markers lie within a region of approximately 18cM, which, it has been shown previously, is likely to contain the A-T gene. The relative positions of these marker loci, and the distance between them was determined in order to construct a detailed map which has allowed a more precise localization of the A-T gene. We have shown that in pairwise linkage analysis the strongest support for linkage to the A-T gene was with the STMY/CJ52.75 locus (Z = 5.59, theta = 0.0). A three-point analysis using the results from STMY/CJ52.75 and the closely linked marker phi 2.22 gave Z = 5.55, theta = 0.03. Despite persisting evidence of some linkage to Thy-1 our results are consistent with the existence of a single A-T locus on chromosome 11q22-23 and our best estimate of the position of this locus places it between NCAM/DRD2 and (STMY/CJ52.75, F2.22) (Z = 6.74), a region of approximately 5cM in males.
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