ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2009
Quantitative ultrasound backscatter for pulsed cavitational ultrasound therapy- histotripsy.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Pooled it
- Characterization of Bubble Cloud Formation and Tissue Ablation Using a High-Frequency Endoscopic Histotripsy System.Ultrasound in medicine & biology · 2026Article
- Quantification of Histotripsy Dosage Using Machine Learning-Enhanced Ultrasound Imaging Analysis: Correlation with Histological Outcomes.Academic radiology · 2026Article
- Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma.Scientific reports · 2026Article
- Monitoring Fractionation in Elastic Tissues Using High Frame-Rate Doppler Ultrasound.Ultrasound in medicine & biology · 2025Article
- Review
- Development of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation.Radiology. Imaging cancer · 2025Review
- Chirp-Coded Subharmonic Imaging With Volterra Filtering: Histotripsy Bubble Cloud Assessment In Vitro and Ex Vivo.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Ultrasonic Nakagami imaging for automatically positioning and identifying the treated lesion induced by histotripsy.Ultrasonics sonochemistry · 2024Article
- Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024Review
- Research progress and clinical evaluation of histotripsy: a narrative review.Annals of translational medicine · 2023Review
- Magic bubbles: utilizing histotripsy to modulate the tumor microenvironment and improve systemic anti-tumor immune responses.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Spatiotemporal local and abscopal cell death and immune responses to histotripsy focused ultrasound tumor ablation.Frontiers in immunology · 2023Article
- Initial Assessment of Boiling Histotripsy for Mechanical Ablation of Ex Vivo Human Prostate Tissue.Ultrasound in medicine & biology · 2023Article
- Quantitative Assessment of Boiling Histotripsy Progression Based on Color Doppler Measurements.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Transcranial Magnetic Resonance-Guided Histotripsy for Brain Surgery: Pre-clinical Investigation.Ultrasound in medicine & biology · 2022Article
- Current state of therapeutic focused ultrasound applications in neuro-oncology.Journal of neuro-oncology · 2022Review
- Transcranial MR-Guided Histotripsy System.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy.Journal for immunotherapy of cancer · 2020Article
- Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Histotripsy is a well-controlled ultrasonic tissue ablation technology that mechanically and progressively fractionates tissue structures using cavitation. The fractionated tissue volume can be monitored with ultrasound imaging because a significant ultrasound backscatter reduction occurs.This paper correlates the ultrasound backscatter reduction with the degree of tissue fractionation characterized by the percentage of remaining normal-appearing cell nuclei on histology.Different degrees of tissue fractionation were generated in vitro in freshly excised porcine kidneys by varying the number of therapeutic ultrasound pulses from 100 to 2000 pulses per treatment location. All ultrasound pulses were 15 cycles at 1 MHz delivered at 100 Hz pulse repetition frequency and 19 MPa peak negative pressure. The results showed that the normalized backscatter intensity decreased exponentially with increasing number of pulses. Correspondingly, the percentage of normal appearing nuclei in the treated area decreased exponentially as well. A linear correlation existed between the normalized backscatter intensity and the percentage of normal appearing cell nuclei in the treated region. This suggests that the normalized backscatter intensity may be a potential quantitative real-time feedback parameter for histotripsy-induced tissue fractionation. This quantitative feedback may allow the prediction of local clinical outcomes, i.e., when a tissue volume has been sufficiently treated.
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Registered trials
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