ArticleWorld journal of gastroenterology2009
Expression of thymidylate synthase and glutathione-s-transferase pi in patients with esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Overcoming chemoresistance in esophageal cancer with synergistic strategies.Frontiers in immunology · 2026Review
- Molecular mechanisms associated with chemoresistance in esophageal cancer.Cellular and molecular life sciences : CMLS · 2022Review
- Inhibition of glutathione metabolism attenuates esophageal cancer progression.Experimental & molecular medicine · 2017Article
- Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population.PloS one · 2015Article
- Review of Cisplatin and oxaliplatin in current immunogenic and monoclonal antibody treatments.Oncology reviews · 2014Review
- Review of Cisplatin and Oxaliplatin in Current Immunogenic and Monoclonal Antibodies Perspective.World journal of oncology · 2014Review
- A pilot study to investigate the role of thymidylate synthase as a marker of prognosis for neoadjuvant chemotherapy in gastric and gastro-oesophageal junction adenocarcinoma.Gastroenterology research and practice · 2013Article
- Glutathione s-transferases in pediatric cancer.Frontiers in oncology · 2011Article
- Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma.World journal of gastroenterology · 2010Article
- Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma.BMC cancer · 2010Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of thymidylate synthase (TS) and glutathione-s-transferase pi (GST-pi) in esophageal squamous cell carcinoma and their association with the clinicopathologic characteristics.
methodsImmunohistochemical methods were used to detect the expression of TS and GST-pi in surgically resected formalin-fixed, paraffin-embedded esophageal squamous cell carcinoma (ESCC) tissue sections from 102 patients (median age, 58 years) and in 28 normal esophageal mucosa (NEM) samples. The relationship between TS and GST-pi expression and clinicopathologic factors was examined.
resultsThe expression of TS and GST-pi was not statistically significantly associated with age of the patients, tumor size, lymph node metastasis, depth of invasion or tumor stage. TS staining was positive in 17.86% of normal esophageal mucosa and in 42.16% of ESCC samples (P < 0.05). The expression level of TS was not only significantly lower in well-differentiated (21.88%) than in poorly-differentiated carcinomas (51.43%, P < 0.05), but was also significantly higher in samples from male patients (46.51%) than from female patients (18.75%, P < 0.05). GST-pi was positively stained in 78.57% of normal esophageal mucosa and in 53.92% of ESCC samples (P < 0.05). The expression level of GST-pi was also significantly higher in well-differentiated carcinomas (65.63%) than in poorly-differentiated carcinomas (35.00%, P < 0.05).
conclusionThe expression of TS and of GST-pi may be used as molecular markers for the characterization of ESCC. Poorly-differentiated cells showed increased expression of TS and reduced expression of GST-pi.
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