ReviewWorld journal of gastroenterology2009
Overview of immunosuppression in liver transplantation.
Review in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.The Cochrane database of systematic reviews · 2018Pooled it
- Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients.The Cochrane database of systematic reviews · 2014Pooled it
- Antibody induction versus corticosteroid induction for liver transplant recipients.The Cochrane database of systematic reviews · 2014Pooled it
- Calcineurin inhibitor minimisation versus continuation of calcineurin inhibitor treatment for liver transplant recipients.The Cochrane database of systematic reviews · 2012Pooled it
- Renal Function Improvement by Telbivudine in Liver Transplant Recipients with Chronic Kidney Disease.BioMed research international · 2017Trial
- Five-year outcomes in liver transplant patients receiving everolimus with or without a calcineurin inhibitor: Results from the CERTITUDE study.Liver international : official journal of the International Association for the Study of the Liver · 2022Observational
- Factors affecting anxiety, depression, and self-care ability in patients who have undergone liver transplantation.World journal of gastroenterology · 2021Article
- Hepatic Encephalopathy: From Metabolic to Neurodegenerative.Neurochemical research · 2021Review
- Article
- Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury.Drug delivery and translational research · 2021Review
- Liposomal Nanosystems in Rheumatoid Arthritis.Pharmaceutics · 2021Review
- Identification of peripheral CD154Clinical and experimental immunology · 2021Article
- Immunosuppressive regimens for adult liver transplant recipients in real-life practice: consensus recommendations from an Italian Working Group.Hepatology international · 2020Review
- Silencing of HLA class I on primary human hepatocytes as a novel strategy for reduction in alloreactivity.Journal of cellular and molecular medicine · 2019Article
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation.PloS one · 2019Article
- Alterations in gut microbial function following liver transplant.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018Article
- Impact of Antibodies That React With Liver Tissue and Donor-Specific Anti-HLA Antibodies in Pediatric Idiopathic Posttransplantation Hepatitis.Transplantation · 2017Article
- Succinct guide to liver transplantation for medical students.Annals of medicine and surgery (2012) · 2016Review
- Liver transplantation significantly improves global functioning and cerebral processing.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2016Article
- Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice.Toxicology mechanisms and methods · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continued advances in surgical techniques and immunosuppressive therapy have allowed liver transplantation to become an extremely successful treatment option for patients with end-stage liver disease. Beginning with the revolutionary discovery of cyclosporine in the 1970s, immunosuppressive regimens have evolved greatly and current statistics confirm one-year graft survival rates in excess of 80%. Immunosuppressive regimens include calcineurin inhibitors, anti-metabolites, mTOR inhibitors, steroids and antibody-based therapies. These agents target different sites in the T cell activation cascade, usually by inhibiting T cell activation or via T cell depletion. They are used as induction therapy in the immediate peri- and post-operative period, as long-term maintenance medications to preserve graft function and as salvage therapy for acute rejection in liver transplant recipients. This review will focus on existing immunosuppressive agents for liver transplantation and consider newer medications on the horizon.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.