ArticleHPB surgery : a world journal of hepatic, pancreatic and biliary surgery2009
Malignant rhabdoid tumour of the liver in the young adult: report of first two cases.
Article in HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review.BMC gastroenterology · 2022Review
- Primary Malignant Rhabdoid Tumour of the Liver in Adult Male: a Diagnostic and Therapeutic Challenge.Journal of gastrointestinal cancer · 2021Article
- Pediatric Primary Hepatic Tumors: Diagnostic Considerations.Diagnostics (Basel, Switzerland) · 2021Review
- Acute severe respiratory syndrome coronavirus-2 treatment overview for pediatrics.Current opinion in pediatrics · 2021Review
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Authors and funding
7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Few cases of malignant rhabdoid tumour (MRT) of the liver are reported in literature and always in paediatric patients. We report the first two cases of young adults submitted to hepatic resection for MRT of the liver. A major liver resection was performed in both cases. The histology showed round or fusiform, loosely cohesive cells. The cytoplasm contained abundant eosinophilic inclusions, which caused the nuclei to be located in eccentric locations, giving the characteristic rhabdoid appearance. The immunohistochemical study was performed, and characteristic lack of nuclear INI1 protein expression was found. In a case surgery was associated to chemoradiotherapy. One patient died at 48 months followup for tumour recurrence. The other is still alive at 25 months followup. MRTs are rare tumours of pediatric age with poor prognosis. Hypothetical less malignant behaviour in the young adults could be supposed. Therefore an aggressive surgical and oncological treatment seems justified.
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