ArticleEnvironmental health perspectives2009
Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025Review
- Pesticide exposure associated with mild cognitive impairment & depression among agricultural workers: Case control study in rural India.The Indian journal of medical research · 2025Article
- Pesticide Exposure and Its Association with Parkinson's Disease: A Case-Control Analysis.Cellular and molecular neurobiology · 2024Article
- Organophosphorus pesticide exposure biomarkers in a Mexican population.Environmental science and pollution research international · 2021Article
- Article
- Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates.Current protocols · 2021Article
- Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development.Minerva medica · 2019Review
- Molecular detection of M. tuberculosis and M. bovis and hematological and biochemical analyses in agricultural sprayers exposed to pesticides: A cross-sectional study in Punjab, Pakistan during 2014-2016.Journal of exposure science & environmental epidemiology · 2017Article
- Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand.Environmental research · 2015Article
- Blood α-synuclein in agricultural pesticide handlers in central Washington State.Environmental research · 2015Article
- Blood acetylcholinesterase and butyrylcholinesterase as biomarkers of cholinesterase depression among pesticide handlers.Occupational and environmental medicine · 2014Article
- Suicide mortality among agricultural workers in a region with intensive tobacco farming and use of pesticides in Brazil.Journal of occupational and environmental medicine · 2014Article
- Arylesterase phenotype-specific positive association between arylesterase activity and cholinesterase specific activity in human serum.International journal of environmental research and public health · 2014Article
- Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.Toxicology · 2013Review
- Correlation between Cholinesterase and Paraoxonase 1 Activities:Case Series of Pesticide Poisoning Subjects.BioImpacts : BI · 2013Article
- PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos.Toxicology and applied pharmacology · 2012Article
- Cholinesterase and paraoxonase (PON1) enzyme activities in Mexican-American mothers and children from an agricultural community.Journal of exposure science & environmental epidemiology · 2012Article
- Serum paraoxonase-1 (PON-1) genotype and exposure to organophosphorous insectides--is there a high-risk population?Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2011Review
- Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.Environmental health perspectives · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAnimal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals.
objectivesWe evaluated the relation between plasma PON1 status and BuChE inhibition among OP-exposed agricultural pesticide handlers.
methodsAgricultural pesticide handlers in Washington State were recruited during the 2006 and 2007 spray seasons when they were seen for follow-up ChE testing by collaborating medical providers as part of a statewide monitoring program. Blood samples were collected from 163 participants and tested for PON1 status based on plasma PON1 activity [arylesterase (AREase)] and PON1 Q192R genotype. We evaluated percent change in BuChE activity from baseline level in relation to PON1 status.
resultsWe observed significantly greater BuChE inhibition among QQ homozygotes relative to RR homozygotes (p = 0.036). Lower levels of plasma PON1 activity were significantly associated with greater BuChE inhibition (p = 0.004). These associations remained after adjustment for year, days since baseline test, age, and OP exposure in the last 30 days.
conclusionsWe found that both low PON1 catalytic efficiency (i.e., the Q192 alloform) and low plasma PON1 activity were associated with BuChE inhibition among OP-exposed agricultural pesticide handlers. Corroborative findings from future studies with prospective collection of blood samples for PON1 testing, more sensitive markers of OP-related effects, and larger sample sizes are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.