Evidence map›Paper›PMID 19750095›Full record

ArticleEnvironmental health perspectives2009

Hormesis: a conversation with a critic.

Edward J Calabrese

Abstract readComment
In one paragraph

Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Phytotoxic Effect of InvasiveMolecules (Basel, Switzerland) · 2019
    Article
  4. Article
  5. Review
  6. Hormesis: a brief reply to an advocate.Environmental health perspectives · 2010
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Edward J CalabreseDepartment of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, MA 01003 USA. edwardc@schoolph.umass.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this commentary I respond to points raised in the commentary by Mushak [Ad hoc and fast forward: the science and control of hormesis growth and development. Environ Health Perspect 117:1333-1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology. DISCUSSION: In this commentary I demonstrate that Mushak's analysis contains critical statistical errors and misunderstandings of statistical concepts that invalidate its conclusions concerning the frequency of hormesis in the toxicologic literature.

conclusionsIn his commentary Mushak offers no significant new conceptual insights, and his key technical criticisms of hormesis frequency findings are unfounded.

Indexed as

Dose-Response Relationship, DrugEnvironmental PollutantsModels, TheoreticalEnvironmental Pollutantsadaptive responsebiphasicdose responsehormesishormeticlinear dose responserisk assessmentthreshold dose responseU-shaped

Identifiers

PMID19750095
PMCPMC2737007

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.