ArticlePloS one2009
O antigen allows B. parapertussis to evade B. pertussis vaccine-induced immunity by blocking binding and functions of cross-reactive antibodies.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Pertussis Vaccines Scarcely Provide Protection againstVaccines · 2024Review
- Article
- Evolution and Conservation ofFrontiers in microbiology · 2020Review
- Enhancement of immune response against Bordetella spp. by disrupting immunomodulation.Scientific reports · 2019Article
- Article
- Bordetella bronchiseptica Glycosyltransferase Core Mutants Trigger Changes in Lipid A Structure.Journal of the American Society for Mass Spectrometry · 2019Article
- Article
- Outer-Membrane-Vesicle-Associated O Antigen, a Crucial Component for Protecting AgainstFrontiers in immunology · 2018Article
- Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014.Medicine · 2017Observational
- Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms.PloS one · 2017Article
- Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species.BMC genomics · 2016Article
- Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A.Journal of bacteriology · 2015Article
- Bordetella parapertussis survives inside human macrophages in lipid raft-enriched phagosomes.Infection and immunity · 2014Article
- Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen.Infection and immunity · 2012Article
- Lack of cross-protection against Bordetella holmesii after pertussis vaccination.Emerging infectious diseases · 2012Article
- Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/- mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis.Infection and immunity · 2011Article
- Antigenic Variation among Bordetella: Bordetella bronchiseptica strain MO149 expresses a novel o chain that is poorly immunogenic.The Journal of biological chemistry · 2010Article
- Acellular pertussis vaccination facilitates Bordetella parapertussis infection in a rodent model of bordetellosis.Proceedings. Biological sciences · 2010Article
- The O antigen is a critical antigen for the development of a protective immune response to Bordetella parapertussis.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although the prevalence of Bordetella parapertussis varies dramatically among studies in different populations with different vaccination regimens, there is broad agreement that whooping cough vaccines, composed only of B. pertussis antigens, provide little if any protection against B. parapertussis. In C57BL/6 mice, a B. pertussis whole-cell vaccine (wP) provided modest protection against B. parapertussis, which was dependent on IFN-gamma. The wP was much more protective against an isogenic B. parapertussis strain lacking O-antigen than its wild-type counterpart. O-antigen inhibited binding of wP-induced antibodies to B. parapertussis, as well as antibody-mediated opsonophagocytosis in vitro and clearance in vivo. aP-induced antibodies also bound better in vitro to the O-antigen mutant than to wild-type B. parapertussis, but aP failed to confer protection against wild-type or O antigen-deficient B. parapertussis in mice. Interestingly, B. parapertussis-specific antibodies provided in addition to either wP or aP were sufficient to very rapidly reduce B. parapertussis numbers in mouse lungs. This study identifies a mechanism by which one pathogen escapes immunity induced by vaccination against a closely related pathogen and may explain why B. parapertussis prevalence varies substantially between populations with different vaccination strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.