ArticleNature structural & molecular biology2009
Structural basis for autoregulation of the zinc transporter YiiP.
Article in Nature structural & molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 256 citations in OpenAlex.
- A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency.The Journal of biological chemistry · 2012Trial
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Zinc homeostasis imbalance: Potential therapeutic value in neurodegenerative diseases.Neural regeneration research · 2026Article
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- Is CepA frommSphere · 2025Article
- A flow equilibrium model controlling cytoplasmic transition metal cation pools and preventing mis-metalation as exemplified for zinc homeostasis.Journal of bacteriology · 2025Review
- Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer.Protein & cell · 2025Article
- Structural and functional insights of ZnT1 C-terminal domain as a regulator of zinc transport.Scientific reports · 2025Article
- Metal-α-Helix Peptide Frameworks.Journal of the American Chemical Society · 2025Article
- Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1.The Biochemical journal · 2025Article
- Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms.FEBS letters · 2025Article
- The efflux system CdfX exports zinc that cannot be transported by ZntA inJournal of bacteriology · 2024Article
- Structural insights into human zinc transporter ZnT1 mediated ZnEMBO reports · 2024Article
- In vitro reconstitution of transition metal transporters.The Journal of biological chemistry · 2024Review
- Assessment of the hypothetical protein BB0616 in the murine infection ofInfection and immunity · 2024Article
- A flow equilibrium of zinc in cells ofJournal of bacteriology · 2024Article
- Structural insights into the calcium-coupled zinc export of human ZnT1.Science advances · 2024Article
- Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms.International journal of molecular sciences · 2024Review
- Flipping the switch: dynamic modulation of membrane transporter activity in bacteria.Microbiology (Reading, England) · 2023Review
- Energy coupling and stoichiometry of ZneLife · 2023Article
70 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-A resolution structure of the zinc transporter YiiP from Escherichia coli reveals a richly charged dimer interface stabilized by zinc binding. Site-directed fluorescence resonance energy transfer (FRET) measurements and mutation-activity analysis suggest that zinc binding triggers hinge movements of two electrically repulsive cytoplasmic domains pivoting around four salt bridges situated at the juncture of the cytoplasmic and transmembrane domains. These highly conserved salt bridges interlock transmembrane helices at the dimer interface, where they are well positioned to transmit zinc-induced interdomain movements to reorient transmembrane helices, thereby modulating coordination geometry of the active site for zinc transport. The cytoplasmic domain of YiiP is a structural mimic of metal-trafficking proteins and the metal-binding domains of metal-transporting P-type ATPases. The use of this common structural module to regulate metal coordination chemistry may enable a tunable transport activity in response to cytoplasmic metal fluctuations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.