ArticleNature neuroscience2009
AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 99 citations in OpenAlex.
- Article
- H3 Acetylation-Induced Basal Progenitor Generation and Neocortex Expansion Depends on the Transcription Factor Pax6.Biology · 2024Article
- TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB.Cancers · 2022Article
- Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.PLoS biology · 2022Article
- BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.Frontiers in cell and developmental biology · 2022Article
- Article
- 3D promoter architecture re-organization during iPSC-derived neuronal cell differentiation implicates target genes for neurodevelopmental disorders.Progress in neurobiology · 2021Article
- Article
- Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders.BMC psychiatry · 2020Article
- Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.Nature neuroscience · 2020Article
- Transcriptional Regulators and Human-Specific/Primate-Specific Genes in Neocortical Neurogenesis.International journal of molecular sciences · 2020Review
- TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition.Cell death & disease · 2020Article
- Article
- Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.iScience · 2018Article
- Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.Nature neuroscience · 2018Article
- AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation.Journal of experimental neuroscience · 2018Article
- AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior.Molecular psychiatry · 2017Article
- Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice andThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteins.World journal of psychiatry · 2016Review
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
19 authors at 9 institutions in 6 countries.
Funding
Abstract
An important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2gamma regulates laminar fate in a region-specific manner. Deletion of AP2gamma (also known as Tcfap2c) during development resulted in a specific reduction of upper layer neurons in the occipital cortex, leading to impaired function and enhanced plasticity of the adult visual cortex. AP2gamma functions in apical progenitors, and its absence resulted in mis-specification of basal progenitors in the occipital cortex at the time at which upper layer neurons were generated. AP2gamma directly regulated the basal progenitor fate determinants Math3 (also known as Neurod4) and Tbr2, and its overexpression promoted the generation of layer II/III neurons in a time- and region-specific manner. Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex.
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