ArticleJournal of Alzheimer's disease : JAD2009
Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease.Acta neuropathologica communications · 2025Article
- An assembly of galanin-galanin receptor signaling network.Journal of cell communication and signaling · 2021Article
- Increased Serum Neuropeptide Galanin Level Is a Predictor of Cognitive Dysfunction in Patients with Hip Fracture.Disease markers · 2021Observational
- Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability.The Journal of comparative neurology · 2020Article
- (Neuro) Peptides, Physical Activity, and Cognition.Journal of clinical medicine · 2020Review
- Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome.Developmental neurobiology · 2019Article
- Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis.Annals of neurology · 2018Article
- Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.Molecular neurodegeneration · 2017Article
- Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.Brain structure & function · 2017Article
- Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease.Acta neuropathologica communications · 2017Article
- Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease.Neurobiology of aging · 2016Article
- Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders.Acta neuropathologica communications · 2015Article
- Hippocampal plasticity during the progression of Alzheimer's disease.Neuroscience · 2015Review
- GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment.Neuropharmacology · 2014Article
- Intravenous immunoglobulin reduces tau pathology and preserves neuroplastic gene expression in the 3xTg mouse model of Alzheimer's disease.Current Alzheimer research · 2014Article
- Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease.Neurobiology of disease · 2012Article
- Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease.Journal of chemical neuroanatomy · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Fibers containing galanin (GAL) hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis neurons in late stage Alzheimer's disease (AD), yet the molecular consequences of this phenomenon are unknown. To determine whether GAL alters the expression of genes critical to CBF cell survival in AD, single cell microarray analysis was used to determine mRNA levels within nucleus basalis neurons lacking GAL innervation from subjects who died with a clinical diagnosis of no cognitive impairment (NCI) compared to nucleus basalis neurons from AD cases either lacking GAL hyperinnervation (AD/GAL-) or those displaying prominent GAL hyperinnervation (AD/GAL+). Levels of mRNAs encoding putatively neuroprotective proteins such as the GluR2 Ca(2)-impermeable glutamate receptor subunit, superoxide dismutase 2, and the GLUT2 glucose transporter were significantly decreased in AD/GAL- nucleus basalis neurons compared to NCI and AD/GAL+ neurons. By contrast, mRNAs encoding calpain catalytic and regulatory subunits, which may contribute to cell death in AD, were increased in AD/GAL- compared to NCI and AD/GAL+ neurons. Hence, GAL fiber hyperinnervation appears to preserve the expression of genes subserving multiple neuroprotective pathways suggesting that GAL overexpression regulates CBF neuron survival in AD.
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