ArticleAJNR. American journal of neuroradiology2010
Enhanced detection of diffusion reductions in Creutzfeldt-Jakob disease at a higher B factor.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Diagnostic value of diffusion-weighted brain magnetic resonance imaging in patients with sporadic Creutzfeldt-Jakob disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Creutzfeldt-Jakob disease: Case report and literature review.Radiology case reports · 2025Article
- Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.Human brain mapping · 2022Article
- Beyond the embolus: "do not miss" diffusion abnormalities of ischaemic and non-ischaemic neurological disease.Insights into imaging · 2017Review
- Neuroradiology of human prion diseases, diagnosis and differential diagnosis.La Radiologia medica · 2017Review
- Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study.NeuroImage. Clinical · 2017Article
- Role of neuroimaging in multidisciplinary approach towards Non-Alzheimer's dementia.Insights into imaging · 2015Article
- Familial Creutzfeldt-Jakob disease with the E200K mutation: longitudinal neuroimaging from asymptomatic to symptomatic CJD.Journal of neurology · 2015Article
- Neuroimaging of rapidly progressive dementias, part 2: prion, inflammatory, neoplastic, and other etiologies.AJNR. American journal of neuroradiology · 2014Review
- Multiparameter MR imaging in the 6-OPRI variant of inherited prion disease.AJNR. American journal of neuroradiology · 2013Article
- Imaging of the 6-OPRI mutation prion disease: an entity distinct from typical Creutzfeldt-Jakob disease?AJNR. American journal of neuroradiology · 2013Article
- Susceptibility of domestic cats to chronic wasting disease.Journal of virology · 2013Article
- Article
- Subcortical volumes in long-term abstinent alcoholics: associations with psychiatric comorbidity.Alcoholism, clinical and experimental research · 2011Article
- Putaminal volume and diffusion in early familial Creutzfeldt-Jakob disease.Journal of the neurological sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeDiffusion-weighted imaging (DWI) is sensitive to the cerebral manifestations of human prion diseases. The magnitude of diffusion weighting, termed "b factor," has only been evaluated at the standard b = 1000 s/mm(2). This is the first rigorous evaluation of b = 2000 s/mm(2) in Creutzfeldt-Jakob Disease (CJD). MATERIALS AND
methodsWe compared DWI characteristics of 13 patients with CJD and 15 healthy controls at b = 1000 s/mm(2) and b = 2000 s/mm(2). Apparent diffusion coefficients (ADC) were computed and analyzed for the whole brain by voxel-wise analysis (by SPM5) as well as in anatomically defined volumes of interest (by FSL FIRST).
resultsMeasured ADC was significantly lower (by approximately 5%-15%) at b = 2000 s/mm(2) than at b = 1000 s/mm(2) and significantly lower in patients than in controls. The differences between patients and controls were greater and more extensive at b = 2000 s/mm(2) than at b = 1000 s/mm(2) in the expected regions (thalamus, putamen, and caudate nucleus).
conclusionsBecause higher b factors change the absolute value of observed ADC, as well as lesion detection, care should be taken when combining studies using different b factors. While the clinical application of high b factors is currently limited by a low signal intensity-to-noise ratio, it may offer more information in questionable cases, and our results confirm and extend the central role of diffusion imaging in human prion diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.