ArticleJournal of bacteriology2009
Evidence that human Chlamydia pneumoniae was zoonotically acquired.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 8 citations in OpenAlex.
- Identifying Infectious Agents in Snakes (Boidae and Pythonidae) with and Without Respiratory Disease.Animals : an open access journal from MDPI · 2025Article
- From coughs to complications: the story ofJournal of medical microbiology · 2025Review
- Human Infection withChina CDC weekly · 2025Article
- Chlamydiosis in Animals.Animals : an open access journal from MDPI · 2024Review
- Direct targeting of host microtubule and actin cytoskeletons by a chlamydial pathogenic effector protein.Journal of cell science · 2024Article
- A molecular survey of Chlamydia spp. infection in commercial poultry and detection of Chlamydia pneumoniae in a commercial turkey flock in Iran.Veterinary medicine and science · 2023Article
- Intraspecies characterization of bacteria via evolutionary modeling of protein domains.Scientific reports · 2022Article
- Pathogenomes and variations in Shiga toxin production among geographically distinct clones ofMicrobial genomics · 2022Article
- Detection of Chlamydial DNA from Mediterranean Loggerhead Sea Turtles in Southern Italy.Animals : an open access journal from MDPI · 2022Article
- Chronic wasting associated with Chlamydia pneumoniae in three ex situ breeding facilities for tropical frogs.Antonie van Leeuwenhoek · 2020Article
- Pathogenomes of Atypical Non-shigatoxigenicFrontiers in microbiology · 2020Article
- Insights Into aFrontiers in cellular and infection microbiology · 2020Article
- Genetic and Virulence Profiles of EnteroaggregativeFrontiers in cellular and infection microbiology · 2020Article
- Diversity in Chlamydial plasmids.PloS one · 2020Article
- Review
- Review
- The Genetic Transformation of Chlamydia pneumoniae.mSphere · 2018Article
- Discovery of Human-Specific ImmunodominantmSphere · 2018Article
- Comprehensive Molecular Serology of HumanmSphere · 2018Article
- Single Nucleotide Polymorphism Analysis Indicates Genetic Distinction and Reduced Diversity of Swine-Associated Methicillin ResistantFrontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Zoonotic infections are a growing threat to global health. Chlamydia pneumoniae is a major human pathogen that is widespread in human populations, causing acute respiratory disease, and has been associated with chronic disease. C. pneumoniae was first identified solely in human populations; however, its host range now includes other mammals, marsupials, amphibians, and reptiles. Australian koalas (Phascolarctos cinereus) are widely infected with two species of Chlamydia, C. pecorum and C. pneumoniae. Transmission of C. pneumoniae between animals and humans has not been reported; however, two other chlamydial species, C. psittaci and C. abortus, are known zoonotic pathogens. We have sequenced the 1,241,024-bp chromosome and a 7.5-kb cryptic chlamydial plasmid of the koala strain of C. pneumoniae (LPCoLN) using the whole-genome shotgun method. Comparative genomic analysis, including pseudogene and single-nucleotide polymorphism (SNP) distribution, and phylogenetic analysis of conserved genes and SNPs against the human isolates of C. pneumoniae show that the LPCoLN isolate is basal to human isolates. Thus, we propose based on compelling genomic and phylogenetic evidence that humans were originally infected zoonotically by an animal isolate(s) of C. pneumoniae which adapted to humans primarily through the processes of gene decay and plasmid loss, to the point where the animal reservoir is no longer required for transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.