ReviewCurrent opinion in immunology2009
Human leukocyte antigen antibodies in chronic transplant vasculopathy-mechanisms and pathways.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation.Current stem cell reports · 2022Review
- Successful Desensitization by Post-Centrifugal Plasma Filtration in Two Highly Sensitized Heart and Lung Transplant Recipients.Annals of laboratory medicine · 2020Article
- Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection.Journal of immunology research · 2017Review
- Phosphorylated S6 kinase and S6 ribosomal protein are diagnostic markers of antibody-mediated rejection in heart allografts.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2015Article
- IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Influence of immune responses in gene/stem cell therapies for muscular dystrophies.BioMed research international · 2014Review
- Interplay between immune responses to HLA and non-HLA self-antigens in allograft rejection.Human immunology · 2013Review
- Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Role of alloimmunity and autoimmunity in allograft rejection.Clinical transplants · 2013Article
- Role of antibodies to self-antigens in chronic allograft rejection: potential mechanism and therapeutic implications.Human immunology · 2012Review
- Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigens.Expert review of clinical immunology · 2012Review
- The link between major histocompatibility complex antibodies and cell proliferation.Transplantation reviews (Orlando, Fla.) · 2011Review
- Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs.Gastroenterology · 2011Review
- Alloimmunity and autoimmunity in chronic rejection.Current opinion in organ transplantation · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transplant recipients exhibiting posttransplant antibodies are at a higher risk for acute and chronic antibody mediated rejection (AMR). The primary alloantigens recognized by antibodies in recipients with AMR are the highly polymorphic HLA class I and class II molecules expressed on the surface of the endothelial cells (ECs) of the graft. Traditionally, anti-HLA antibodies were thought to mediate graft injury through complement-dependent mechanisms. However, recent studies indicate that antibodies can also contribute to alterations in EC function through complement-independent mechanisms by transducing intracellular signals. Anti-HLA antibodies transduce signals that are both pro-inflammatory and pro-proliferative suggesting mechanistic roles in acute and chronic AMR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.