ArticlePain2009
Role of SIP30 in the development and maintenance of peripheral nerve injury-induced neuropathic pain.
Article in Pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
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- Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia.BMC veterinary research · 2025Article
- Phylogenetic analysis of mammalian SIP30 sequences indicating accelerated adaptation of functional domain in primates.Biochemistry and biophysics reports · 2024Article
- SIP30 involvement in vesicle exocytosis from PC12 cells.Biochemistry and biophysics reports · 2024Article
- Early decompression promotes motor recovery after cervical spinal cord injury in rats with chronic cervical spinal cord compression.Scientific reports · 2022Article
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- Genomic inbreeding trends, influential sire lines and selection in the global Thoroughbred horse population.Scientific reports · 2020Article
- A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.BMC genetics · 2018Article
- DNMT3a methylation in neuropathic pain.Journal of pain research · 2017Article
- An early granulocyte colony-stimulating factor treatment attenuates neuropathic pain through activation of mu opioid receptors on the injured nerve.Scientific reports · 2016Article
- SNAP25 ameliorates sensory deficit in rats with spinal cord transection.Molecular neurobiology · 2014Article
- SIP30 is required for neuropathic pain-evoked aversion in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Moonlighting functions of the NRZ (mammalian Dsl1) complex.Frontiers in cell and developmental biology · 2014Review
- p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI).Molecular pain · 2012Article
- MicroRNAs as potential therapeutics for treating spinal cord injury.Neural regeneration research · 2012Article
- Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury.PloS one · 2012Article
- SIP30 is regulated by ERK in peripheral nerve injury-induced neuropathic pain.The Journal of biological chemistry · 2009Article
Corrections and comments
- Erratum issuedWang, Xidao [added]
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Using the chronic constriction injury (CCI) model of neuropathic pain, we profiled gene expression in the rat spinal cord, and identified SIP30 as a gene whose expression was elevated after CCI. SIP30 was previously shown to interact with SNAP25, but whose function was otherwise unknown. We now show that in the spinal cord, SIP30 was present in the dorsal horn laminae where the peripheral nociceptive inputs first synapse, co-localizing with nociception-related neuropeptides CGRP and substance P. With the onset of neuropathic pain after CCI surgery, SIP30 mRNA and protein levels increased in the ipsilateral side of the spinal cord, suggesting a potential association between SIP30 and neuropathic pain. When CCI-upregulated SIP30 was inhibited by intrathecal antisense oligonucleotide administration, neuropathic pain was attenuated. This neuropathic pain-reducing effect was observed both during neuropathic pain onset following CCI, and after neuropathic pain was fully established, implicating SIP30 involvement in the development and maintenance phases of neuropathic pain. Using a secretion assay in PC12 cells, anti-SIP30 siRNA decreased the total pool of synaptic vesicles available for exocytosis, pointing to a potential function for SIP30. These results suggest a role of SIP30 in the development and maintenance of peripheral nerve injury-induced neuropathic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.