Evidence map›Paper›PMID 19747958›Full record

ReviewMolecular and cellular endocrinology2010

Hormones in synergy: regulation of the pituitary gonadotropin genes.

Varykina G Thackray, Pamela L Mellon, Djurdjica Coss

Abstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Trial
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  17. Review
  18. Review
  19. Article
  20. GnRH-A Key Regulator of FSH.Endocrinology · 2019
    Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Varykina G ThackrayDepartment of Reproductive Medicine, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093-0674, USA.
Pamela L Mellon
Djurdjica Coss

Funding

The Interaction of Neuroendocrine Repro. Function and Metabolic SignalingU54HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1999 to 2013
$18.0M
The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAWSON, MARK ANDREW · 1985 to 2020
$7.5M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUSR01DK044838 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1991 to 2011
$3.8M
The Role of AP-1 in the GonadotropeR01HD057549 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COSS, DJURDJICA · 2009 to 2013
$1.6M
PITUITARY GONADOTROPIN GENE REGULATIONR01HD020377 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1985 to 2010
$1.5M
GnRH-Regulated Transcriptome in the GonadotropeR21HD058752 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COSS, DJURDJICA · 2009 to 2010
$425k
Integration of PR and FoxO Signaling in Pituitary GonadotropesK01DK080467 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THACKRAY, VARYKINA G · 2008 to 2010
$420k
Regulation of Immediate Early Genes by GnRH in the GonadotropeR03HD054595 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COSS, DJURDJICA · 2008 to 2009
$155k
The Role of Smads and AR in FSHbeta Gene ExpressionF32DK065437 · NIDDK · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI THACKRAY, VARYKINA G · 2003 to 2005
$139k
Regulation of Gonadotropin Expression by GnRH PulsesF32HD041301 · NICHD · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI COSS, DJURDJICA · 2001 to 2002
$79k
NICHD NIH HHS F32 HD041301NICHD NIH HHS F32 HD41301NICHD NIH HHS P50 HD012303NICHD NIH HHS R01 HD020377NICHD NIH HHS R01 HD057549NICHD NIH HHS R03 HD054595NICHD NIH HHS R21 HD058752NICHD NIH HHS T32 HD007203NICHD NIH HHS U54 HD012303NIDDK NIH HHS F32 DK065437NIDDK NIH HHS K01 DK080467NIDDK NIH HHS R01 DK044838
6 · The paper itself

Abstract

The precise interplay of hormonal influences that governs gonadotropin hormone production by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic gonadotropin-releasing hormone (GnRH), activin and steroids. However, most studies of hormonal regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gonadotrope have been limited to analyses of the isolated actions of individual hormones. LHbeta and FSHbeta subunits have distinct patterns of expression during the menstrual/estrous cycle as a result of the integration of activin, GnRH, and steroid hormone action. In this review, we focus on studies that delineate the interplay among these hormones in the regulation of LHbeta and FSHbeta gene expression in gonadotrope cells and discuss how signaling cross-talk contributes to differential expression. We also discuss how recent technological advances will help identify additional factors involved in the differential hormonal regulation of LH and FSH.

Indexed as

ActivinsAnimalsFollicle Stimulating HormoneGene Expression RegulationGonadotrophsGonadotropin-Releasing HormoneHumansLuteinizing HormonePituitary GlandReproductionActivinsFollicle Stimulating HormoneGonadotropin-Releasing HormoneLuteinizing Hormone

Identifiers

PMID19747958
PMCPMC2815122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.