ArticleBrain research2009
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.
Article in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Downregulation of neuronal DRD2 drives microglia synaptic pruning and results in cognitive deficits by promoting CCL2 release in a rat model of chronic migraine.The journal of headache and pain · 2026Article
- Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis.Nature communications · 2024Article
- Dopamine D2 receptor regulates cortical synaptic pruning in rodents.Nature communications · 2021Article
- Neurobehavioral changes arising from early life dopamine signaling perturbations.Neurochemistry international · 2020Review
- Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.Molecular psychiatry · 2020Article
- Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats.Neural plasticity · 2016Article
- Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.Traffic (Copenhagen, Denmark) · 2015Review
- D1 receptors regulate dendritic morphology in normal and stressed prelimbic cortex.Psychoneuroendocrinology · 2015Article
- Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors.Frontiers in cellular neuroscience · 2015Article
- Developmental origins of brain disorders: roles for dopamine.Frontiers in cellular neuroscience · 2013Review
- Adolescent dopamine slows spine maturation.Nature neuroscience · 2013Article
- Age-dependent regulation of synaptic connections by dopamine D2 receptors.Nature neuroscience · 2013Article
- Dendritic spine pathology in schizophrenia.Neuroscience · 2013Review
- An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice.PLoS biology · 2012Article
- The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding.Behavioural brain research · 2011Article
- The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate.The European journal of neuroscience · 2010Article
- Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D(1), D(2), and D(4) dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D(1) knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D(2) knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D(4) knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D(1) and possibly D(2) receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological, and biochemical studies of the prefrontal cortex in dopamine receptor knockout mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.