Evidence map›Paper›PMID 19747698›Full record

ReviewPhytochemistry2009

Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes.

Alan R Brash

Abstract readReview
In one paragraph

Review in Phytochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 133 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  7. Epoxyalcohol Synthase Branch of Lipoxygenase Cascade.Current issues in molecular biology · 2024
    Review
  8. Article
  9. Review
  10. Identification and Characterization of Jasmonic Acid Biosynthetic Genes inInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Review
  13. Cytochrome P450 Enzymes and Drug Metabolism in Humans.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Green Leaf Volatile-Burst inFrontiers in plant science · 2021
    Article
  16. Jasmonates: what ALLENE OXIDE SYNTHASE does for plants.Journal of experimental botany · 2019
    Review
  17. Article
  18. Review
  19. Ligand Access Channels in Cytochrome P450 Enzymes: A Review.International journal of molecular sciences · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alan R BrashDepartment of Pharmacology, and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, USA. alan.brash@vanderbilt.edu
Vanderbilt University · US

Funding

Novel Catalases and their ProductsR01GM074888 · NIGMS · VANDERBILT UNIVERSITY · PI BRASH, ALAN R. · 2006 to 2013
$2.4M
NIGMS NIH HHS GM-074888NIGMS NIH HHS R01 GM074888
6 · The paper itself

Abstract

The existence of CYP5, CYP8A, and the CYP74 enzymes specialized for reaction with fatty acid peroxide substrates presents opportunities for a "different look" at the catalytic cycle of the cytochrome P450s. This review considers how the properties of the peroxide-metabolizing enzymes are distinctive, and how they tie in with those of the conventional monooxygenase enzymes. Some unusual reactions of each class have parallels in the other. As enzyme reactions and P450 structures emerge there will be possibilities for finding their special properties and edging this knowledge into the big picture.

Indexed as

Aldehyde-LyasesCytochrome P-450 Enzyme SystemIntramolecular OxidoreductasesModels, BiologicalPlant ProteinsPlantsThromboxane-A SynthaseAldehyde-LyasesCytochrome P-450 Enzyme Systemhydroperoxide isomerasehydroperoxide lyaseIntramolecular OxidoreductasesPlant Proteinsprostacyclin synthetaseThromboxane-A Synthase

Identifiers

PMID19747698
PMCPMC2783490
OpenAlexW2026467437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.